Org game results -- Major Leagues
Regular season
| Results |
| Date | # | Inn | Away | R | Home | R | Win | Loss | Save | GWRBI |
| 4/8/1981 | | | Phi | 14 | Cin | 7 | Carlton | Seaver | | Trillo |
| 4/9/1981 | | | Tor | 3 | Det | 7 | Morris | Clancy | | Kemp |
| 4/9/1981 | | | Tex | 4 | NYA | 9 | Bird | Matlack | Davis | Cerone |
| 4/9/1981 | | 11 | Oak | 5 | Min | 2 | Jones | Corbett | | Stanley |
| 4/9/1981 | | | Cal | 2 | Sea | 1 | Zahn | Abbott | Aase | Carew |
| 4/9/1981 | | | NYN | 2 | ChN | 3 | Reuschel | Zachry | Tidrow | Buckner |
| 4/9/1981 | | | Mon | 1 | Pit | 0 | Rogers | Bibby | | Carter |
| 4/9/1981 | | 10 | Hou | 2 | LA | 1 | Smith,D | Howe | LaCorte | Walling |
| 4/9/1981 | | | SD | 10 | SF | 9 | Urrea | Minton | | Bonilla |
| 4/10/1981 | | | KC | 2 | Bal | 1 | Gura | Stone | Quisenberry | Aikens |
| 4/10/1981 | | 11 | ChA | 5 | Bos | 1 | Hoyt | Clear | | Fisk |
| 4/10/1981 | | 11 | Oak | 2 | Min | 3 | O'Connor | Langford | | Johnston |
| 4/10/1981 | | | Cal | 7 | Sea | 1 | Jefferson | Gleaton | | |
| 4/10/1981 | | | Cin | 6 | Atl | 1 | Soto | Boggs | | Griffey |
| 4/10/1981 | | | SD | 0 | SF | 2 | Whitson | Lollar | | Evans |
| 4/11/1981 | | | Mil | 5 | Cle | 3 | Cleveland | Blyleven | Fingers | Simmons |
| 4/11/1981 | | | Tor | 2 | Det | 1 | Stieb | Wilcox | Jackson | Moseby |
| 4/11/1981 | | | Tex | 2 | NYA | 3 | May | Comer | Gossage | |
| 4/11/1981 | | | Oak | 0 | Min | 2 | Williams | Keough | | Castino |
| 4/11/1981 | | | Cal | 6 | Sea | 4 | Witt | Bannister | Aase | Lynn |
| 4/11/1981 | | | NYN | 1 | ChN | 6 | McGlothen | Jones | | McGlothen |
| 4/11/1981 | | | Phi | 2 | StL | 3 | Sutter | Reed,R | | Lezcano |
| 4/11/1981 | | | Cin | 9 | Atl | 4 | Moskau | Perry | | Concepcion |
| 4/11/1981 | | | Hou | 13 | LA | 7 | Sutton | Hooton | Smith,D | Cruz |
| 4/11/1981 | | | SD | 0 | SF | 11 | Alexander | Eichelberger | | Cabell |
| 4/12/1981 | | | KC | 9 | Bal | 4 | Leonard | Flanagan | | Washington |
| 4/12/1981 | | | ChA | 7 | Bos | 3 | Dotson | Tanana | | Bernazard |
| 4/12/1981 | | | Mil | 3 | Cle | 4 | Monge | Augustine | | Manning |
| 4/12/1981 | | | Tor | 3 | Det | 6 | Rucker | Barlow | Rozema | Peters |
| 4/12/1981 | | 11 | Tex | 4 | NYA | 3 | Johnson,JH | Gossage | | Sample |
| 4/12/1981 | | | Oak | 11 | Min | 5 | McCatty | Redfern | | Revering |
| 4/12/1981 | | | Cal | 5 | Sea | 1 | Forsch | Clay | | |
| 4/12/1981 | | | NYN | 10 | ChN | 6 | Leary | Kravec | | Trevino |
| 4/12/1981 | | | Mon | 4 | Pit | 8 | Tekulve | Ratzer | | Parker |
| 4/12/1981 | | | Phi | 6 | StL | 11 | Otten | Christenson | | Porter |
| 4/12/1981 | | | Cin | 1 | Atl | 7 | Montefusco | Pastore | | Chambliss |
| 4/12/1981 | | 11 | Hou | 6 | LA | 2 | LaCorte | Castillo | | Bergman |
| 4/12/1981 | | 10 | SD | 4 | SF | 5 | Minton | Welsh | | Morgan |
| 4/13/1981 | | | Bal | 9 | Bos | 13 | Clear | Ford | | Rice |
| 4/13/1981 | | | NYA | 5 | Tor | 8 | Clancy | Bird | Willis | Mayberry |
| 4/13/1981 | | | Oak | 10 | Cal | 7 | Owchinko | Travers | | Babitt |
| 4/13/1981 | | | Pit | 2 | Phi | 4 | Carlton | Candelaria | Reed,R | Matthews |
| 4/13/1981 | | | Atl | 2 | Hou | 4 | Knepper | Niekro | Smith,D | Reynolds |
| 4/13/1981 | | | Cin | 3 | SD | 0 | Seaver | Wise | | Concepcion |
| 4/13/1981 | | | LA | 4 | SF | 2 | Welch | Ripley | Howe | Baker |
| 4/14/1981 | | | Oak | 1 | Cal | 5 | Zahn | Norris | | Hobson |
| 4/14/1981 | | 10 | Mil | 6 | ChA | 8 | Lamp | Fingers | | Lemon |
| 4/14/1981 | | | Det | 4 | KC | 6 | Splittorff | Morris | Quisenberry | Aikens |
| 4/14/1981 | | | Min | 0 | Sea | 1 | Abbott | Koosman | Andersen,L | Bochte |
| 4/14/1981 | | | Cle | 1 | Tex | 8 | Matlack | Waits | | Bell |
| 4/14/1981 | | | Atl | 2 | Hou | 4 | Niekro | Walk | LaCorte | Reynolds |
| 4/14/1981 | | | Cin | 6 | SD | 2 | Berenyi | Curtis | | Oester |
| 4/14/1981 | | | LA | 1 | SF | 2 | Minton | Valenzuela | | Clark |
| 4/15/1981 | | | Bal | 6 | Bos | 5 | Martinez,D | Torrez | Stoddard | Lowenstein |
| 4/15/1981 | | | NYA | 6 | Tor | 5 | May | Todd | Davis | Nettles |
| 4/15/1981 | | | Oak | 6 | Cal | 1 | Langford | Jefferson | | Page |
| 4/15/1981 | | | Mil | 5 | ChA | 2 | Haas | Burns | Fingers | Thomas |
| 4/15/1981 | | | Det | 3 | KC | 1 | Rozema | Gura | Saucier | Whitaker |
| 4/15/1981 | | | Min | 10 | Sea | 4 | Arroyo | Gleaton | Corbett | Jackson,R |
| 4/15/1981 | | | Cle | 1 | Tex | 3 | Medich | Barker | Comer | Oliver |
| 4/15/1981 | | | ChN | 1 | Mon | 4 | Rogers | Reuschel | Fryman | Carter |
| 4/15/1981 | | | StL | 4 | NYN | 3 | Sutter | Reardon | | Hernandez |
| 4/15/1981 | | 10 | Pit | 5 | Phi | 6 | Proly | Romo | | Matthews |
| 4/15/1981 | | | Atl | 0 | Hou | 2 | Ryan | Boggs | | Howe |
| 4/15/1981 | | | Cin | 5 | SD | 0 | Soto | Mura | | Foster |
| 4/15/1981 | | 12 | LA | 6 | SF | 5 | Stewart | Lavelle | Reuss | Landreaux |
| 4/16/1981 | | | Cle | 0 | Mil | 9 | Caldwell | Garland | | Molitor |
| 4/16/1981 | | | Det | 5 | Tor | 9 | Stieb | Wilcox | Jackson | Moseby |
| 4/16/1981 | | | Oak | 4 | Cal | 1 | Keough | Witt | Jones | Armas |
| 4/16/1981 | | | ChN | 2 | Mon | 15 | Sanderson | McGlothen | | Dawson |
| 4/16/1981 | | | StL | 3 | NYN | 1 | Rincon | Scott | Sutter | Rincon |
| 4/16/1981 | | | Pit | 10 | Phi | 4 | Robinson,D | Ruthven | | Law |
| 4/17/1981 | | | Det | 10 | Tor | 4 | Bailey | Leal | | Kemp |
| 4/17/1981 | | | Min | 2 | Cal | 3 | Forsch | Verhoeven | | Carew |
| 4/17/1981 | | | Bos | 4 | ChA | 1 | Eckersley | Dotson | Burgmeier | Remy |
| 4/17/1981 | | | Bal | 0 | KC | 6 | Leonard | Stone | | Otis |
| 4/17/1981 | | | Sea | 0 | Oak | 3 | McCatty | Bannister | | Henderson |
| 4/17/1981 | | | NYA | 5 | Tex | 2 | Guidry | Darwin | Gossage | Jackson |
| 4/17/1981 | | | ChN | 6 | Phi | 4 | Eastwick | Christenson | Martz | Durham |
| 4/17/1981 | | 13 | SF | 4 | Atl | 3 | Holland | Garber | | Evans |
| 4/17/1981 | | | StL | 1 | Cin | 3 | LaCoss | Sorensen | Hume | Driessen |
| 4/17/1981 | | | Pit | 2 | Hou | 4 | Sutton | Rhoden | Smith,D | Puhl |
| 4/17/1981 | | | LA | 4 | SD | 5 | Eichelberger | Sutcliffe | Lollar | Jones |
| 4/18/1981 | | | Cle | 7 | Mil | 4 | Blyleven | Slaton | | Hargrove |
| 4/18/1981 | | | Det | 4 | Tor | 3 | Saucier | Barlow | | |
| 4/18/1981 | | | Min | 17 | Cal | 0 | Redfern | Travers | | Smalley |
| 4/18/1981 | | | Bos | 0 | ChA | 2 | Trout | Tanana | | Bernazard |
| 4/18/1981 | | | Sea | 3 | Oak | 6 | Kingman | Clay | Jones | Revering |
| 4/18/1981 | | | NYA | 8 | Tex | 3 | John | Comer | | Cerone |
| 4/18/1981 | | | Mon | 1 | NYN | 2 | Reardon | Gullickson | Allen | Trevino |
| 4/18/1981 | | | ChN | 2 | Phi | 4 | McGraw | Eastwick | | Bowa |
| 4/18/1981 | | | SF | 9 | Atl | 4 | Griffin | Montefusco | | Griffin |
| 4/18/1981 | | | StL | 4 | Cin | 7 | Seaver | Shirley | Moskau | Knight |
| 4/18/1981 | | | Pit | 4 | Hou | 1 | Candelaria | Ruhle | Romo | Easler |
| 4/18/1981 | | | LA | 0 | SD | 2 | Wise | Valenzuela | | Smith |
| 4/19/1981 | | | Det | 9 | Tor | 3 | Morris | Bomback | | Parrish |
| 4/19/1981 | | | Bos | 0 | ChA | 3 | Baumgarten | Crawford | | Luzinski |
| 4/19/1981 | | 11 | Bal | 2 | KC | 3 | Quisenberry | Martinez,T | | White |
| 4/19/1981 | | | NYA | 7 | Tex | 8 | Hough | Castro | Comer | Sundberg |
| 4/19/1981 | | | ChN | 3 | Phi | 1 | Reuschel | Espinosa | Capilla | Durham |
| 4/19/1981 | | | SF | 1 | Atl | 7 | Niekro | Ripley | | Chambliss |
| 4/19/1981 | | | Pit | 1 | Hou | 2 | Smith,D | Romo | | Cedeno |
| 4/19/1981 | | | LA | 5 | SD | 2 | Welch | Curtis | | Baker |
| 4/19/1981 | 1 | | Sea | 3 | Oak | 5 | Norris | Abbott | Jones | Revering |
| 4/19/1981 | 1 | | Mon | 4 | NYN | 0 | Burris | Swan | | Dawson |
| 4/19/1981 | 2 | | Sea | 0 | Oak | 3 | Langford | Parrott | Owchinko | Gross |
| 4/19/1981 | 2 | 10 | Mon | 6 | NYN | 3 | Sosa | Falcone | Fryman | Dawson |
| 4/20/1981 | | | Tex | 11 | Bos | 4 | Medich | Torrez | | Sample |
| 4/20/1981 | | | Det | 2 | NYA | 5 | May | Rozema | | |
| 4/20/1981 | | | Mil | 5 | Tor | 0 | Vuckovich | Todd | | Cooper |
| 4/20/1981 | | | Sea | 3 | Cal | 2 | Drago | Hassler | | Henderson |
| 4/20/1981 | | | Cle | 4 | KC | 3 | Denny | Quisenberry | Spillner | Hargrove |
| 4/20/1981 | | | Min | 2 | Oak | 1 | Koosman | Keough | Corbett | Jackson,R |
| 4/20/1981 | | | Phi | 2 | Mon | 1 | Bystrom | Rogers | McGraw | Trillo |
| 4/20/1981 | | | ChN | 4 | StL | 7 | Forsch | McGlothen | Kaat | Hendrick |
| 4/20/1981 | | | LA | 5 | Hou | 2 | Hooton | Andujar | Stewart | Garvey |
| 4/20/1981 | | | SF | 5 | SD | 4 | Blue | Mura | Holland | Morgan |
| 4/21/1981 | | | Tex | 5 | Bos | 3 | Jenkins | Tudor | Comer | Bell |
| 4/21/1981 | | | Det | 4 | NYA | 3 | Wilcox | Bird | Saucier | Hebner |
| 4/21/1981 | | | Mil | 3 | Tor | 2 | Haas | Stieb | Fingers | Cooper |
| 4/21/1981 | | | Sea | 5 | Cal | 6 | Hassler | Bannister | Aase | Baylor |
| 4/21/1981 | | | Bal | 5 | ChA | 7 | Burns | Palmer | Hoyt | Johnson |
| 4/21/1981 | | | Cle | 2 | KC | 5 | Gura | Waits | Martin | Brett,G |
| 4/21/1981 | | | Min | 3 | Oak | 6 | McCatty | Erickson | Owchinko | Gross |
| 4/21/1981 | | | Phi | 2 | Mon | 4 | Sanderson | Ruthven | Fryman | Cromartie |
| 4/21/1981 | | | ChN | 0 | StL | 10 | Rincon | Kravec | | Hendrick |
| 4/21/1981 | | | Atl | 0 | Cin | 7 | Soto | Boggs | | Concepcion |
| 4/21/1981 | | | LA | 5 | Hou | 2 | Reuss | Sprowl | Stewart | Lopes |
| 4/21/1981 | | | SF | 1 | SD | 2 | Boone | Breining | Lollar | Perkins |
| 4/22/1981 | | | Tex | 10 | Bos | 3 | Darwin | Eckersley | | Grubb |
| 4/22/1981 | | | Det | 3 | NYA | 4 | Guidry | Bailey | Gossage | Dent |
| 4/22/1981 | | | Mil | 3 | Tor | 6 | Leal | Caldwell | Jackson | Mayberry |
| 4/22/1981 | | | Sea | 3 | Cal | 6 | Forsch | Clay | Aase | Ford |
| 4/22/1981 | | | Cle | 3 | KC | 1 | Barker | Leonard | Spillner | Orta |
| 4/22/1981 | | | Min | 0 | Oak | 4 | Kingman | Williams | | Armas |
| 4/22/1981 | | | Phi | 0 | Mon | 4 | Gullickson | Christenson | | Scott |
| 4/22/1981 | | | ChN | 7 | StL | 3 | Krukow | Sorensen | | Tracy |
| 4/22/1981 | | | Atl | 8 | Cin | 3 | Perry | LaCoss | | Benedict |
| 4/22/1981 | | | LA | 4 | Hou | 2 | Valenzuela | Sutton | Howe | Cey |
| 4/22/1981 | | 13 | SF | 8 | SD | 7 | Breining | Urrea | Lavelle | May |
| 4/23/1981 | | | Cin | 3 | Hou | 5 | LaCorte | Seaver | Sprowl | Cedeno |
| 4/23/1981 | | | SD | 1 | LA | 5 | Sutcliffe | Wise | Stewart | Cey |
| 4/23/1981 | | 10 | Atl | 4 | SF | 3 | Garber | Lavelle | | |
| 4/23/1981 | 1 | | Bal | 3 | ChA | 11 | Hickey | McGregor | Farmer | Almon |
| 4/23/1981 | 2 | | Bal | 5 | ChA | 3 | Stone | Lamp | Ford | Krenchicki |
| 4/24/1981 | | | ChA | 3 | Det | 1 | Trout | Morris | Hoyt | Baines |
| 4/24/1981 | | | KC | 8 | Mil | 4 | Martin | Slaton | Quisenberry | Aikens |
| 4/24/1981 | | | Tor | 1 | NYA | 3 | John | Bomback | Gossage | Oates |
| 4/24/1981 | | | Cal | 2 | Min | 15 | Redfern | Travers | | Smalley |
| 4/24/1981 | | | Oak | 4 | Sea | 6 | Abbott | Norris | | Simpson |
| 4/24/1981 | | | Phi | 5 | ChN | 4 | Carlton | Reuschel | McGraw | McBride |
| 4/24/1981 | | | Cin | 3 | Hou | 2 | Pastore | Niekro | Hume | Collins |
| 4/24/1981 | | | SD | 2 | LA | 3 | Welch | Curtis | Howe | Guerrero |
| 4/24/1981 | | | Atl | 14 | SF | 5 | Mahler | Lavelle | Camp | Benedict |
| 4/25/1981 | | | Bos | 8 | Bal | 2 | Tanana | Flanagan | Clear | Stapleton |
| 4/25/1981 | | | Tex | 5 | Cle | 1 | Honeycutt | Garland | | Rivers |
| 4/25/1981 | | | ChA | 0 | Det | 2 | Rozema | Baumgarten | Saucier | Parrish |
| 4/25/1981 | | | KC | 4 | Mil | 2 | Gura | Vuckovich | Quisenberry | Brett,G |
| 4/25/1981 | | | Tor | 2 | NYA | 7 | May | Todd | | Gamble |
| 4/25/1981 | | | Cal | 1 | Min | 2 | Koosman | Zahn | Corbett | Engle |
| 4/25/1981 | | | Oak | 10 | Sea | 9 | Langford | Gleaton | Jones | Johnson |
| 4/25/1981 | | 13 | Phi | 7 | ChN | 5 | Proly | Kravec | | Bowa |
| 4/25/1981 | | | NYN | 0 | Mon | 1 | Rogers | Hausman | Fryman | |
| 4/25/1981 | | | StL | 1 | Pit | 4 | Candelaria | Shirley | Romo | Parker |
| 4/25/1981 | | | Cin | 2 | Hou | 1 | Berenyi | Ryan | Moskau | Foster |
| 4/25/1981 | | | SD | 2 | LA | 4 | Forster | Mura | Stewart | Garvey |
| 4/25/1981 | | | Atl | 8 | SF | 4 | Niekro | Blue | | Murphy |
| 4/26/1981 | | | Bos | 16 | Bal | 3 | Eckersley | Palmer | | Rice |
| 4/26/1981 | | | Tex | 3 | Cle | 4 | Blyleven | Matlack | Monge | Diaz |
| 4/26/1981 | | | ChA | 2 | Det | 0 | Burns | Lopez | | Essian |
| 4/26/1981 | | | KC | 4 | Mil | 10 | Fingers | Martin | | Hisle |
| 4/26/1981 | | 16 | Tor | 3 | NYA | 4 | Bird | Barlow | | Werth |
| 4/26/1981 | | | Oak | 3 | Sea | 4 | Andersen,L | Jones | | Simpson |
| 4/26/1981 | | | Phi | 6 | ChN | 3 | Bystrom | Caudill | Reed,R | Trillo |
| 4/26/1981 | | | StL | 6 | Pit | 7 | Robinson,D | Martinez | Romo | Madlock |
| 4/26/1981 | | 14 | Cin | 1 | Hou | 2 | LaCorte | Hume | | Walling |
| 4/26/1981 | | | SD | 4 | LA | 1 | Boone | Reuss | Littlefield | Evans |
| 4/26/1981 | 1 | | Cal | 3 | Min | 5 | Erickson | Witt | Corbett | Engle |
| 4/26/1981 | 1 | | NYN | 2 | Mon | 5 | Burris | Zachry | Fryman | |
| 4/26/1981 | 1 | | Atl | 5 | SF | 1 | Perry | Alexander | | Murphy |
| 4/26/1981 | 2 | | Cal | 3 | Min | 4 | Arroyo | Jefferson | Cooper | Castino |
| 4/26/1981 | 2 | 10 | NYN | 4 | Mon | 3 | Allen | Lee | Miller | Stearns |
| 4/26/1981 | 2 | | Atl | 3 | SF | 6 | Whitson | Boggs | Holland | |
| 4/27/1981 | | 12 | ChA | 3 | Bal | 1 | Lamp | Martinez,T | | Almon |
| 4/27/1981 | | | NYA | 2 | Det | 3 | Bailey | Guidry | Tobik | Parrish |
| 4/27/1981 | | | Tor | 2 | Mil | 4 | Easterly | Barlow | Fingers | Oglivie |
| 4/27/1981 | | | Sea | 11 | Min | 3 | Bannister | Williams | | Randle |
| 4/27/1981 | | | Cal | 8 | Oak | 1 | Forsch | McCatty | | Campaneris |
| 4/27/1981 | | 12 | Bos | 4 | Tex | 8 | Johnson,JH | Campbell | | Sample |
| 4/27/1981 | | | Mon | 10 | Phi | 2 | Gullickson | Ruthven | | Gullickson |
| 4/27/1981 | | | SF | 3 | LA | 9 | Valenzuela | Griffin | | Scioscia |
| 4/28/1981 | | | ChA | 15 | Bal | 5 | Dotson | Stone | | Luzinski |
| 4/28/1981 | | | NYA | 11 | Det | 3 | John | Schatzeder | | Winfield |
| 4/28/1981 | | | Tor | 0 | Mil | 5 | Caldwell | Bomback | | Simmons |
| 4/28/1981 | | | Sea | 4 | Min | 9 | Redfern | Clay | | Jackson,R |
| 4/28/1981 | | | Cal | 6 | Oak | 1 | Renko | Kingman | | Harris |
| 4/28/1981 | | | Bos | 1 | Tex | 5 | Jenkins | Crawford | | Wills |
| 4/28/1981 | | | Pit | 4 | NYN | 8 | Scott | Solomon | | Stearns |
| 4/28/1981 | | 10 | Mon | 6 | Phi | 4 | Fryman | Lyle | | Carter |
| 4/28/1981 | | | Hou | 12 | Atl | 1 | Sutton | Montefusco | | Reynolds |
| 4/28/1981 | | | SD | 2 | Cin | 3 | Moskau | Urrea | | Knight |
| 4/28/1981 | | 14 | SF | 4 | LA | 3 | Minton | Castillo | | Herndon |
| 4/29/1981 | | | ChA | 2 | Bal | 3 | Martinez,D | Farmer | | Murray |
| 4/29/1981 | | | NYA | 5 | Det | 0 | Gossage | Morris | | Gamble |
| 4/29/1981 | | | Tor | 0 | Mil | 1 | Fingers | Barlow | | Molitor |
| 4/29/1981 | | | Cal | 5 | Oak | 4 | Sanchez | Jones | Aase | Ford |
| 4/29/1981 | | | Bos | 4 | Tex | 5 | Darwin | Tudor | Hough | Mendoza |
| 4/29/1981 | | | StL | 7 | ChN | 1 | Rincon | Krukow | | Hernandez |
| 4/29/1981 | | | Pit | 5 | NYN | 2 | Bibby | Roberts | | Parker |
| 4/29/1981 | | | Mon | 1 | Phi | 3 | Carlton | Rogers | | Moreland |
| 4/29/1981 | | | Hou | 5 | Atl | 6 | Walk | Ruhle | Camp | Chambliss |
| 4/29/1981 | | | SD | 9 | Cin | 4 | Lollar | Pastore | Littlefield | Richards |
| 4/29/1981 | | | SF | 4 | LA | 2 | Blue | Welch | Holland | Morgan |
| 4/30/1981 | | | Tor | 6 | Bal | 3 | Jackson | Ford | | Griffin |
| 4/30/1981 | | | Min | 4 | Bos | 0 | Erickson | Tanana | | Smalley |
| 4/30/1981 | | | ChA | 7 | Cle | 5 | Hoyt | Spillner | | Nordhagen |
| 4/30/1981 | | 12 | Mil | 10 | Cal | 11 | D'Acquisto | Vuckovich | | Baylor |
| 4/30/1981 | | | Det | 6 | Sea | 4 | Saucier | Rawley | Tobik | Trammell |
| 4/30/1981 | | | KC | 0 | Tex | 2 | Honeycutt | Gale | | Sundberg |
| 4/30/1981 | | | Pit | 2 | NYN | 5 | Jones | Candelaria | Hausman | Kingman |
| 4/30/1981 | | | Hou | 2 | Atl | 4 | Mahler | Niekro | Camp | Horner |
| 4/30/1981 | | | SD | 10 | Cin | 6 | Mura | LaCoss | | Kennedy |
| 5/1/1981 | | | Min | 6 | Bos | 4 | Verhoeven | Eckersley | Corbett | Jackson,R |
| 5/1/1981 | | | ChA | 2 | Cle | 10 | Denny | Burns | | Thornton |
| 5/1/1981 | | | Mil | 2 | Cal | 4 | Witt | Lerch | D'Acquisto | Lynn |
| 5/1/1981 | | | NYA | 7 | Oak | 14 | Langford | Underwood | | Heath |
| 5/1/1981 | | | Det | 6 | Sea | 4 | Wilcox | Andersen,L | Lopez | Trammell |
| 5/1/1981 | | | KC | 7 | Tex | 3 | Gura | Comer | | White |
| 5/1/1981 | | | Atl | 4 | ChN | 6 | Caudill | Perry | Tidrow | Henderson |
| 5/1/1981 | | | LA | 5 | Mon | 3 | Goltz | Burris | Stewart | Cey |
| 5/1/1981 | | | SD | 6 | NYN | 7 | Zachry | Littlefield | Reardon | Flynn |
| 5/1/1981 | | | Hou | 2 | Pit | 1 | Smith,D | Scurry | | Woods |
| 5/1/1981 | | | Cin | 1 | StL | 2 | Forsch | Soto | Sutter | Hernandez |
| 5/2/1981 | | | Min | 1 | Bos | 2 | Torrez | Williams | Burgmeier | Stapleton |
| 5/2/1981 | | | ChA | 7 | Cle | 10 | Barker | Barrios | | Veryzer |
| 5/2/1981 | | | Mil | 3 | Cal | 5 | Forsch | Haas | | Harris |
| 5/2/1981 | | | NYA | 3 | Oak | 7 | Keough | Guidry | | Johnson |
| 5/2/1981 | | | Det | 4 | Sea | 7 | Bannister | Petry | | Randle |
| 5/2/1981 | | | KC | 2 | Tex | 3 | Johnson,JH | Leonard | | Oliver |
| 5/2/1981 | | | Atl | 8 | ChN | 3 | Garber | Martz | | Horner |
| 5/2/1981 | | 11 | LA | 6 | Mon | 3 | Forster | Ratzer | | Thomas |
| 5/2/1981 | | | SD | 1 | NYN | 0 | Lucas | Lynch | | Richards |
| 5/2/1981 | | | Hou | 2 | Pit | 3 | Rhoden | Knepper | Romo | Madlock |
| 5/2/1981 | | | Cin | 6 | StL | 0 | Berenyi | Shirley | | Oester |
| 5/2/1981 | 1 | | Tor | 2 | Bal | 3 | Palmer | Stieb | Martinez,T | Graham |
| 5/2/1981 | 1 | | SF | 3 | Phi | 6 | Espinosa | Alexander | Reed,R | Boone |
| 5/2/1981 | 2 | | Tor | 2 | Bal | 1 | Leal | McGregor | McLaughlin | Bonnell |
| 5/2/1981 | 2 | | SF | 4 | Phi | 5 | Proly | Whitson | Reed,R | Matthews |
| 5/3/1981 | | | Tor | 0 | Bal | 1 | Stone | Bomback | Stoddard | Dauer |
| 5/3/1981 | | | Min | 7 | Bos | 13 | Campbell | Verhoeven | | Lansford |
| 5/3/1981 | | | ChA | 7 | Cle | 4 | Dotson | Garland | Hickey | Luzinski |
| 5/3/1981 | | | Mil | 8 | Cal | 5 | Cleveland | Renko | Fingers | Cooper |
| 5/3/1981 | | | Det | 12 | Sea | 1 | Morris | Clark | | Trammell |
| 5/3/1981 | | | KC | 1 | Tex | 3 | Jenkins | Splittorff | Schmidt | Oliver |
| 5/3/1981 | | | Atl | 8 | ChN | 7 | Bradford | Smith | Hanna | Murphy |
| 5/3/1981 | | | LA | 13 | Mon | 1 | Valenzuela | Gullickson | | Lopes |
| 5/3/1981 | | | SF | 4 | Phi | 12 | Ruthven | Griffin | | Matthews |
| 5/3/1981 | | | Hou | 1 | Pit | 5 | Bibby | Sutton | | Madlock |
| 5/3/1981 | | | Cin | 4 | StL | 5 | Kaat | Combe | | Templeton |
| 5/3/1981 | 1 | | NYA | 2 | Oak | 4 | McCatty | May | Jones | |
| 5/3/1981 | 1 | | SD | 15 | NYN | 2 | Wise | Roberts | | Salazar |
| 5/3/1981 | 2 | | NYA | 5 | Oak | 3 | John | Kingman | | Murcer |
| 5/3/1981 | 2 | | SD | 4 | NYN | 0 | Curtis | Scott | | Salazar |
| 5/4/1981 | | | Min | 7 | Bal | 3 | Koosman | Martinez,D | Cooper | Hatcher |
| 5/4/1981 | | | NYA | 8 | Cal | 4 | Nelson | Zahn | | Watson |
| 5/4/1981 | | 10 | Bos | 3 | KC | 4 | Quisenberry | Burgmeier | | Wilson |
| 5/4/1981 | | | Mil | 2 | Sea | 1 | Slaton | Allard | Fingers | |
| 5/4/1981 | | 14 | Hou | 6 | ChN | 7 | Martz | Sprowl | | Tyson |
| 5/4/1981 | | | LA | 1 | Mon | 4 | Rogers | Sutcliffe | Fryman | Scott |
| 5/4/1981 | | 11 | SF | 1 | Phi | 2 | Reed,R | Holland | | Moreland |
| 5/4/1981 | | | Atl | 7 | StL | 2 | Hrabosky | Rincon | | Chambliss |
| 5/5/1981 | | | Min | 2 | Bal | 4 | Flanagan | Erickson | Stoddard | Roenicke |
| 5/5/1981 | | | NYA | 4 | Cal | 11 | Travers | Underwood | | Ford |
| 5/5/1981 | | | Bos | 1 | KC | 6 | Gura | Tanana | | Washington |
| 5/5/1981 | | | Det | 8 | Oak | 5 | Rozema | Minetto | Bailey | Cowens |
| 5/5/1981 | | | Mil | 5 | Sea | 2 | Vuckovich | Gleaton | Fingers | Yount |
| 5/5/1981 | | | ChA | 10 | Tex | 7 | Baumgarten | Darwin | Hoyt | Fisk |
| 5/5/1981 | | | Hou | 5 | ChN | 2 | Niekro | Reuschel | | Puhl |
| 5/5/1981 | | 10 | SD | 7 | Mon | 4 | Lucas | Fryman | | Lefebvre |
| 5/5/1981 | | | SF | 2 | NYN | 6 | Hausman | Griffin | | Kingman |
| 5/5/1981 | | | LA | 2 | Phi | 3 | Christenson | Welch | Lyle | Rose |
| 5/5/1981 | | | Atl | 3 | StL | 2 | Boggs | Sorensen | Camp | Murphy |
| 5/6/1981 | | | Min | 14 | Bal | 3 | Arroyo | Palmer | | Smalley |
| 5/6/1981 | | | Cle | 5 | Tor | 3 | Blyleven | McLaughlin | Monge | Harrah |
| 5/6/1981 | | | NYA | 8 | Cal | 4 | Guidry | Witt | Bird | Dent |
| 5/6/1981 | | | Bos | 1 | KC | 6 | Leonard | Eckersley | | Brett,G |
| 5/6/1981 | | | Det | 1 | Oak | 3 | Langford | Wilcox | Owchinko | Revering |
| 5/6/1981 | | | Mil | 12 | Sea | 4 | Cleveland | Parrott | Keeton | Oglivie |
| 5/6/1981 | | | ChA | 4 | Tex | 5 | Hough | Lamp | Comer | Putnam |
| 5/6/1981 | | | Hou | 6 | ChN | 0 | Ryan | Caudill | | Cruz |
| 5/6/1981 | | | SD | 4 | Mon | 3 | Eichelberger | Burris | Lucas | Richards |
| 5/6/1981 | | | SF | 7 | NYN | 6 | Whitson | Miller | Holland | Cabell |
| 5/6/1981 | | | LA | 5 | Phi | 1 | Hooton | Espinosa | | Garvey |
| 5/6/1981 | | | Atl | 5 | StL | 9 | Forsch | Perry | | Hendrick |
| 5/6/1981 | | | Pit | 3 | Cin | 6 | Pastore | Candelaria | Price | Bench |
| 5/7/1981 | | | Cle | 5 | Tor | 7 | Stieb | Monge | Jackson | Ainge |
| 5/7/1981 | | | NYA | 0 | Cal | 3 | Forsch | John | | Ford |
| 5/7/1981 | | 11 | Det | 9 | Oak | 6 | Tobik | McLaughlin | | Cowens |
| 5/7/1981 | | 11 | Mil | 4 | Sea | 2 | Cleveland | Andersen,L | Augustine | Oglivie |
| 5/7/1981 | | 10 | ChA | 2 | Tex | 1 | Hoyt | Johnson,JH | | Almon |
| 5/7/1981 | | | Hou | 3 | ChN | 1 | Knepper | Martz | Smith,D | Howe |
| 5/7/1981 | | | SD | 1 | Mon | 5 | Sanderson | Welsh | | Parrish |
| 5/7/1981 | | | SF | 1 | NYN | 8 | Lynch | Alexander | | Bailor |
| 5/7/1981 | | | LA | 3 | Phi | 4 | Proly | Howe | | Matthews |
| 5/7/1981 | | | Atl | 6 | StL | 10 | Edelen | Niekro | | Oberkfell |
| 5/7/1981 | 1 | 13 | Pit | 5 | Cin | 3 | Camacho | Combe | | Madlock |
| 5/7/1981 | 2 | | Pit | 5 | Cin | 4 | Solomon | LaCoss | Romo | Madlock |
| 5/8/1981 | | | Bos | 5 | Tor | 4 | Torrez | Bomback | Burgmeier | Lansford |
| 5/8/1981 | | | Det | 1 | Cal | 4 | Renko | Morris | | Ford |
| 5/8/1981 | | | KC | 4 | ChA | 3 | Splittorff | Barrios | Martin | Otis |
| 5/8/1981 | | | Cle | 0 | Min | 3 | Williams | Denny | | Powell |
| 5/8/1981 | | 12 | Mil | 8 | Oak | 5 | Fingers | Minetto | | Yount |
| 5/8/1981 | | | NYA | 5 | Sea | 1 | May | Clark | | Dent |
| 5/8/1981 | | | SF | 2 | Mon | 5 | Gullickson | Ripley | Fryman | Carter |
| 5/8/1981 | | | LA | 2 | NYN | 1 | Valenzuela | Scott | Stewart | Monday |
| 5/8/1981 | | | SD | 6 | Phi | 7 | McGraw | Boone | | Trillo |
| 5/8/1981 | | 10 | Pit | 7 | StL | 6 | Romo | Edelen | | Pena |
| 5/8/1981 | | | ChN | 3 | Atl | 1 | Krukow | Montefusco | | Durham |
| 5/8/1981 | | | Hou | 3 | Cin | 4 | Hume | LaCorte | | |
| 5/9/1981 | | | Bos | 7 | Tor | 6 | Rainey | Jackson | Burgmeier | Rice |
| 5/9/1981 | | | Det | 1 | Cal | 6 | Zahn | Schatzeder | | Downing |
| 5/9/1981 | | 11 | KC | 11 | ChA | 7 | Wright | Hoyt | | White |
| 5/9/1981 | | | Cle | 3 | Min | 13 | Redfern | Barker | | Jackson,R |
| 5/9/1981 | | | Mil | 0 | Oak | 6 | Kingman | Slaton | | Stanley |
| 5/9/1981 | | | NYA | 8 | Sea | 5 | LaRoche | Andersen,L | Gossage | Spencer |
| 5/9/1981 | | | SF | 1 | Mon | 2 | Rogers | Blue | Fryman | Carter |
| 5/9/1981 | | | LA | 1 | NYN | 5 | Roberts | Sutcliffe | | Youngblood |
| 5/9/1981 | | | SD | 4 | Phi | 5 | Reed,R | Curtis | | Maddox |
| 5/9/1981 | | | Pit | 2 | StL | 7 | Rincon | Scurry | | Tenace |
| 5/9/1981 | | | ChN | 0 | Atl | 6 | Walk | Reuschel | | Chambliss |
| 5/9/1981 | | | Hou | 9 | Cin | 2 | Andujar | Berenyi | | Howe |
| 5/9/1981 | 1 | | Bal | 7 | Tex | 1 | Martinez,D | Jenkins | | DeCinces |
| 5/9/1981 | 2 | | Bal | 0 | Tex | 2 | Schmidt | Stone | Johnson,JH | Duran |
| 5/10/1981 | | | Bos | 4 | Tor | 3 | Tanana | Barlow | Clear | Lansford |
| 5/10/1981 | | 10 | Det | 5 | Cal | 2 | Saucier | Sanchez | | Papi |
| 5/10/1981 | | | Cle | 1 | Min | 5 | Koosman | Garland | | Ward |
| 5/10/1981 | | | Mil | 3 | Oak | 7 | Norris | Vuckovich | Jones | Patterson |
| 5/10/1981 | | | NYA | 8 | Sea | 10 | Andersen,L | Bird | Abbott | Zisk |
| 5/10/1981 | | | Bal | 7 | Tex | 5 | Stoddard | Hough | Martinez,T | Crowley |
| 5/10/1981 | | | LA | 5 | NYN | 3 | Welch | Miller | Stewart | |
| 5/10/1981 | | 13 | SD | 7 | Phi | 5 | Wise | Lyle | | Perkins |
| 5/10/1981 | | | Pit | 0 | StL | 1 | Sutter | Jackson | | Iorg |
| 5/10/1981 | | | Hou | 7 | Cin | 3 | Niekro | Hume | Sambito | Puhl |
| 5/10/1981 | 1 | | SF | 4 | Mon | 2 | Minton | Lee | | Evans |
| 5/10/1981 | 2 | | SF | 3 | Mon | 2 | Lavelle | Sosa | Minton | Smith |
| 5/11/1981 | | | Bos | 4 | Tor | 2 | Eckersley | Todd | Clear | Allenson |
| 5/11/1981 | | 10 | Cle | 12 | ChA | 11 | Spillner | Burns | | Hargrove |
| 5/11/1981 | | | Tex | 10 | KC | 7 | Honeycutt | Gura | | Oliver |
| 5/11/1981 | | | Pit | 3 | Atl | 4 | Perry | Camacho | Camp | |
| 5/11/1981 | | | Hou | 3 | Cin | 4 | Hume | LaCorte | | Concepcion |
| 5/12/1981 | | | Sea | 0 | Det | 6 | Wilcox | Bannister | | Kemp |
| 5/12/1981 | | | Cal | 2 | Mil | 6 | Haas | Forsch | | Simmons |
| 5/12/1981 | | 10 | Oak | 6 | NYA | 5 | Owchinko | LaRoche | | Henderson |
| 5/12/1981 | | | Bal | 14 | Tor | 2 | Palmer | Stieb | | Belanger |
| 5/12/1981 | | | Cle | 9 | ChA | 5 | Waits | Hickey | | Bannister |
| 5/12/1981 | | 10 | Tex | 5 | KC | 4 | Comer | Martin | | Putnam |
| 5/12/1981 | | | Bos | 6 | Min | 5 | Tudor | Erickson | Burgmeier | Evans |
| 5/12/1981 | | | Pit | 1 | Atl | 3 | Camp | Solomon | Hanna | Chambliss |
| 5/12/1981 | | | ChN | 2 | Cin | 1 | Tidrow | Soto | | Henderson |
| 5/12/1981 | | | StL | 3 | Hou | 6 | Knepper | Forsch | LaCorte | Puhl |
| 5/12/1981 | | | Mon | 3 | LA | 0 | Sosa | Stewart | Fryman | Cromartie |
| 5/12/1981 | | | NYN | 1 | SD | 2 | Eichelberger | Zachry | Lucas | |
| 5/12/1981 | | | Phi | 4 | SF | 3 | Espinosa | Lavelle | Lyle | Matthews |
| 5/13/1981 | | | Sea | 8 | Det | 0 | Clark | Petry | | Paciorek |
| 5/13/1981 | | | Cal | 10 | Mil | 3 | Renko | Caldwell | | Ott |
| 5/13/1981 | | | Oak | 2 | NYA | 3 | John | Keough | Gossage | Murcer |
| 5/13/1981 | | | Bal | 8 | Tor | 7 | Ford | Bomback | Martinez,T | Krenchicki |
| 5/13/1981 | | | Cle | 1 | ChA | 4 | Barrios | Denny | Lamp | Bernazard |
| 5/13/1981 | | | Bos | 5 | Min | 1 | Torrez | Arroyo | | |
| 5/13/1981 | | | Pit | 3 | Atl | 1 | Bibby | Montefusco | Romo | Berra |
| 5/13/1981 | | | ChN | 4 | Cin | 5 | Seaver | Tidrow | Hume | Oester |
| 5/13/1981 | | | StL | 4 | Hou | 1 | Shirley | Sutton | Kaat | Tenace |
| 5/13/1981 | | 10 | Mon | 3 | LA | 4 | Reuss | Ratzer | | Cey |
| 5/13/1981 | | 12 | NYN | 4 | SD | 5 | Urrea | Miller | | Bonilla |
| 5/13/1981 | | | Phi | 2 | SF | 1 | Bystrom | Ripley | McGraw | McBride |
| 5/14/1981 | | | Cal | 3 | Mil | 7 | Slaton | Zahn | | Hisle |
| 5/14/1981 | | | Oak | 2 | NYA | 1 | Norris | May | Jones | Picciolo |
| 5/14/1981 | | | Bal | 6 | Tor | 4 | Stewart | Jackson | Stoddard | Singleton |
| 5/14/1981 | | | Tex | 3 | KC | 4 | Quisenberry | Medich | | Geronimo |
| 5/14/1981 | | | Bos | 5 | Min | 2 | Tanana | Williams | Campbell | Evans |
| 5/14/1981 | | | ChN | 1 | Cin | 8 | Berenyi | Reuschel | | Knight |
| 5/14/1981 | | 11 | StL | 2 | Hou | 1 | Otten | Andujar | | Braun |
| 5/14/1981 | | | Mon | 0 | LA | 2 | Valenzuela | Fryman | Stewart | Lopes |
| 5/14/1981 | | | NYN | 3 | SD | 0 | Scott | Curtis | | Kingman |
| 5/14/1981 | | | Phi | 8 | SF | 4 | Ruthven | Blue | | Matthews |
| 5/15/1981 | | | KC | 5 | Bos | 1 | Gale | Crawford | | Otis |
| 5/15/1981 | | | Tor | 0 | Cle | 3 | Barker | Leal | | Thornton |
| 5/15/1981 | | | Cal | 6 | Det | 1 | Witt | Morris | | Grich |
| 5/15/1981 | | 10 | Oak | 7 | Mil | 6 | Jones | Easterly | Owchinko | Armas |
| 5/15/1981 | | | Tex | 7 | ChA | 5 | Comer | Farmer | | Rivers |
| 5/15/1981 | | | Bal | 0 | Min | 1 | Cooper | Martinez,D | | Engle |
| 5/15/1981 | | | Cin | 3 | Pit | 4 | Tekulve | Bair | Romo | Foli |
| 5/15/1981 | | 10 | StL | 5 | Atl | 4 | Sutter | Bradford | | Oberkfell |
| 5/15/1981 | | | ChN | 2 | Hou | 1 | Caudill | Niekro | Tidrow | Thompson |
| 5/15/1981 | | | NYN | 2 | LA | 9 | Welch | Jones | | Garvey |
| 5/15/1981 | | 10 | Phi | 2 | SD | 3 | Littlefield | McGraw | | Richards |
| 5/15/1981 | | 10 | Mon | 5 | SF | 4 | Ratzer | Holland | Bahnsen | Dawson |
| 5/16/1981 | | | KC | 5 | Bos | 2 | Gura | Eckersley | Quisenberry | McRae |
| 5/16/1981 | | | Tor | 6 | Cle | 7 | Lacey | Willis | Monge | Hargrove |
| 5/16/1981 | | | Cal | 2 | Det | 5 | Rozema | Rau | Saucier | Whitaker |
| 5/16/1981 | | | Oak | 8 | Mil | 6 | Kingman | Augustine | Jones | Picciolo |
| 5/16/1981 | | | Sea | 1 | NYA | 2 | Underwood | Gleaton | Gossage | Winfield |
| 5/16/1981 | | | Tex | 0 | ChA | 4 | Burns | Darwin | | Squires |
| 5/16/1981 | | | Bal | 6 | Min | 1 | Stone | Koosman | | Murray |
| 5/16/1981 | | 11 | Cin | 3 | Pit | 2 | Price | Jackson | Combe | Vail |
| 5/16/1981 | | | StL | 10 | Atl | 3 | Martinez | Boggs | | Oberkfell |
| 5/16/1981 | | 10 | ChN | 4 | Hou | 5 | Andujar | Tidrow | | Ashby |
| 5/16/1981 | | | NYN | 4 | LA | 6 | Goltz | Roberts | Stewart | Russell |
| 5/16/1981 | | | Phi | 8 | SD | 1 | Christenson | Lollar | | Christenson |
| 5/16/1981 | | | Mon | 4 | SF | 5 | Griffin | Lee | Minton | Herndon |
| 5/17/1981 | | | KC | 11 | Bos | 1 | Leonard | Tudor | | Wilson |
| 5/17/1981 | | 12 | Cal | 5 | Det | 3 | Aase | Tobik | | Baylor |
| 5/17/1981 | | | Oak | 12 | Mil | 2 | Jones | Haas | | Gross |
| 5/17/1981 | | | Sea | 2 | NYA | 4 | Guidry | Bannister | Gossage | Winfield |
| 5/17/1981 | | 10 | Tex | 2 | ChA | 1 | Johnson,JH | Hoyt | | Rivers |
| 5/17/1981 | | | Bal | 4 | Min | 1 | Palmer | Erickson | Martinez,T | DeCinces |
| 5/17/1981 | | 11 | Cin | 4 | Pit | 3 | Moskau | Romo | Combe | Collins |
| 5/17/1981 | | 10 | StL | 3 | Atl | 4 | Camp | Kaat | | Hubbard |
| 5/17/1981 | | | ChN | 1 | Hou | 3 | Knepper | Krukow | Andujar | Reynolds |
| 5/17/1981 | | | NYN | 3 | LA | 4 | Howe | Allen | | Garvey |
| 5/17/1981 | | | Phi | 4 | SD | 5 | Eichelberger | Espinosa | Lucas | Jones |
| 5/17/1981 | | | Mon | 3 | SF | 11 | Alexander | Burris | | Cabell |
| 5/17/1981 | 1 | | Tor | 7 | Cle | 8 | Monge | McLaughlin | | |
| 5/17/1981 | 2 | | Tor | 3 | Cle | 7 | Blyleven | Garvin | | Diaz |
| 5/18/1981 | | | Oak | 2 | Bal | 6 | McGregor | Keough | | Murray |
| 5/18/1981 | | | Sea | 1 | Bos | 12 | Torrez | Clark | | Lansford |
| 5/18/1981 | | | Cal | 4 | Cle | 7 | Denny | Renko | Monge | Manning |
| 5/18/1981 | | | Tex | 2 | Det | 9 | Petry | Matlack | | Wockenfuss |
| 5/18/1981 | | | KC | 13 | NYA | 6 | Martin | John | | McRae |
| 5/18/1981 | | | ChA | 3 | Tor | 2 | Trout | Bomback | Hoyt | Morrison |
| 5/18/1981 | | 12 | Phi | 6 | LA | 5 | Espinosa | Sutcliffe | | Unser |
| 5/18/1981 | | | Mon | 2 | SD | 1 | Sanderson | Lucas | Fryman | Dawson |
| 5/18/1981 | | | NYN | 3 | SF | 2 | Reardon | Minton | Miller | Kingman |
| 5/19/1981 | | | Oak | 3 | Bal | 2 | Norris | Flanagan | | Newman |
| 5/19/1981 | | | Sea | 3 | Bos | 8 | Tanana | Parrott | Clear | Stapleton |
| 5/19/1981 | | 12 | Cal | 9 | Cle | 8 | D'Acquisto | Stanton | | Grich |
| 5/19/1981 | | | Tex | 4 | Det | 7 | Schatzeder | Schmidt | Lopez | Hebner |
| 5/19/1981 | | 11 | Min | 7 | Mil | 5 | Corbett | Keeton | | Baker |
| 5/19/1981 | | | KC | 3 | NYA | 1 | Gale | Davis | Quisenberry | Washington |
| 5/19/1981 | | 10 | ChA | 2 | Tor | 1 | Barrios | Barlow | Hoyt | |
| 5/19/1981 | | | Cin | 10 | ChN | 8 | Moskau | Eastwick | Bair | Oester |
| 5/19/1981 | | 13 | Atl | 3 | Pit | 1 | Hrabosky | Cruz | Montefusco | Benedict |
| 5/19/1981 | | | Hou | 8 | StL | 0 | Sutton | Shirley | | Howe |
| 5/19/1981 | | | Phi | 5 | LA | 4 | Ruthven | Sutcliffe | Reed,R | Moreland |
| 5/19/1981 | | | Mon | 1 | SD | 2 | Boone | Sosa | Littlefield | Jones |
| 5/19/1981 | | 10 | NYN | 3 | SF | 1 | Falcone | Minton | Miller | Flynn |
| 5/20/1981 | | | Cal | 2 | Bal | 7 | Martinez,D | Witt | | DeCinces |
| 5/20/1981 | | | Oak | 3 | Bos | 1 | McCatty | Crawford | Jones | Heath |
| 5/20/1981 | | | Sea | 1 | Cle | 0 | Allard | Barker | Andersen,L | Bochte |
| 5/20/1981 | | | Tex | 1 | Det | 9 | Morris | Jenkins | | Parrish |
| 5/20/1981 | | | Min | 8 | Mil | 3 | Williams | Slaton | | Wynegar |
| 5/20/1981 | | | KC | 4 | NYA | 3 | Gura | Nelson | Quisenberry | Wilson |
| 5/20/1981 | | | ChA | 2 | Tor | 1 | Dotson | Todd | | Bernazard |
| 5/20/1981 | | | Cin | 8 | ChN | 9 | Smith | Combe | | Henderson |
| 5/20/1981 | | | Atl | 10 | Pit | 6 | Walk | Rhoden | | Ramirez |
| 5/20/1981 | | | Hou | 2 | StL | 7 | Sorensen | Niekro | | Hernandez |
| 5/20/1981 | | | Phi | 5 | LA | 2 | Carlton | Hooton | McGraw | Trillo |
| 5/20/1981 | | | Mon | 10 | SD | 3 | Sosa | Lucas | | Montanez |
| 5/20/1981 | | | NYN | 6 | SF | 2 | Harris | Griffin | | Jorgensen |
| 5/21/1981 | | | Cal | 0 | Bal | 5 | Palmer | Rau | | Singleton |
| 5/21/1981 | | | Oak | 1 | Bos | 11 | Eckersley | Kingman | | Perez |
| 5/21/1981 | | | Sea | 3 | Cle | 2 | Gleaton | Stanton | Andersen,L | Bochte |
| 5/21/1981 | | | Min | 5 | Mil | 1 | Redfern | Vuckovich | | Castino |
| 5/21/1981 | | | Cin | 6 | ChN | 4 | Price | Tidrow | Combe | Knight |
| 5/21/1981 | | | Hou | 1 | StL | 4 | Martin | Ryan | Sutter | Hernandez |
| 5/22/1981 | | | Bal | 4 | Det | 2 | McGregor | Wilcox | Stoddard | Bumbry |
| 5/22/1981 | | | Bos | 0 | Mil | 5 | Haas | Tudor | | Thomas |
| 5/22/1981 | | | Cle | 6 | NYA | 7 | LaRoche | Lacey | | Rodriguez |
| 5/22/1981 | | | ChA | 0 | Cal | 8 | Forsch | Burns | | Downing |
| 5/22/1981 | | | Min | 0 | KC | 2 | Leonard | Koosman | | White |
| 5/22/1981 | | | Tor | 3 | Oak | 1 | Stieb | Langford | McLaughlin | Mayberry |
| 5/22/1981 | | | Tex | 4 | Sea | 2 | Darwin | Bannister | Comer | Bell |
| 5/22/1981 | | | Mon | 0 | ChN | 2 | Krukow | Lea | | Henderson |
| 5/22/1981 | | 14 | Phi | 4 | Pit | 3 | Lyle | Camacho | | Davis,D |
| 5/22/1981 | | | NYN | 8 | StL | 6 | Allen | Sutter | | Brooks |
| 5/22/1981 | | | SD | 7 | Atl | 8 | Hanna | Boone | | Washington |
| 5/22/1981 | | | LA | 7 | Cin | 13 | Hume | Reuss | | Bench |
| 5/22/1981 | | | SF | 3 | Hou | 4 | Andujar | Alexander | Smith,D | Cruz |
| 5/23/1981 | | | Bal | 7 | Det | 10 | Tobik | Stewart | Saucier | Wockenfuss |
| 5/23/1981 | | | Bos | 2 | Mil | 9 | Lerch | Torrez | | Yount |
| 5/23/1981 | | | Cle | 1 | NYA | 7 | Righetti | Waits | | Piniella |
| 5/23/1981 | | 14 | ChA | 8 | Cal | 5 | Hoyt | Jefferson | | Bernazard |
| 5/23/1981 | | | Min | 1 | KC | 2 | Martin | Erickson | | Otis |
| 5/23/1981 | | | Tor | 1 | Oak | 3 | Keough | Bomback | Jones | Spencer |
| 5/23/1981 | | | Tex | 7 | Sea | 5 | Comer | Drago | | Putnam |
| 5/23/1981 | | | Mon | 4 | ChN | 2 | Burris | Reuschel | Fryman | Dawson |
| 5/23/1981 | | | Phi | 3 | Pit | 1 | Espinosa | Solomon | McGraw | Smith |
| 5/23/1981 | | | NYN | 3 | StL | 6 | Forsch | Falcone | Kaat | Hernandez |
| 5/23/1981 | | | SD | 2 | Atl | 1 | Welsh | Perry | Lollar | Kennedy |
| 5/23/1981 | | | LA | 1 | Cin | 4 | Soto | Valenzuela | | Bench |
| 5/23/1981 | | | SF | 5 | Hou | 2 | Whitson | Ruhle | Minton | Herndon |
| 5/24/1981 | | | Cle | 7 | NYA | 3 | Denny | May | | Hargrove |
| 5/24/1981 | | | ChA | 4 | Cal | 0 | Trout | Zahn | | LeFlore |
| 5/24/1981 | | | Min | 6 | KC | 4 | Arroyo | Gale | Corbett | Adams |
| 5/24/1981 | | | Tex | 1 | Sea | 2 | Rawley | Schmidt | | Anderson,J |
| 5/24/1981 | | 12 | Mon | 5 | ChN | 2 | Fryman | Capilla | Sosa | Raines |
| 5/24/1981 | | | Phi | 2 | Pit | 4 | Tekulve | Proly | Scurry | Pena |
| 5/24/1981 | | | NYN | 0 | StL | 4 | Shirley | Scott | | Iorg |
| 5/24/1981 | | | SD | 0 | Atl | 10 | Niekro | Wise | | Benedict |
| 5/24/1981 | | | SF | 2 | Hou | 6 | Sutton | Blue | Sambito | |
| 5/24/1981 | 1 | | Bal | 3 | Det | 10 | Petry | Martinez,D | | Peters |
| 5/24/1981 | 1 | | Bos | 1 | Mil | 2 | Caldwell | Clear | Fingers | Moore,C |
| 5/24/1981 | 1 | | Tor | 3 | Oak | 6 | Underwood | Clancy | Owchinko | Gross |
| 5/24/1981 | 1 | | LA | 2 | Cin | 4 | Seaver | Welch | Hume | Nolan |
| 5/24/1981 | 2 | | Bal | 5 | Det | 3 | Ford | Schatzeder | Stoddard | Dempsey |
| 5/24/1981 | 2 | | Bos | 4 | Mil | 1 | Rainey | Slaton | | Evans |
| 5/24/1981 | 2 | | Tor | 0 | Oak | 5 | Norris | Garvin | | Johnson |
| 5/24/1981 | 2 | | LA | 2 | Cin | 10 | Berenyi | Goltz | | Nolan |
| 5/25/1981 | | | NYA | 8 | Bal | 7 | Davis | Stoddard | Gossage | Nettles |
| 5/25/1981 | | | Cle | 5 | Bos | 8 | Burgmeier | Barker | | Rice |
| 5/25/1981 | | | Det | 5 | Mil | 1 | Morris | Augustine | | Kemp |
| 5/25/1981 | | | Tor | 0 | Cal | 6 | Witt | Todd | | Hobson |
| 5/25/1981 | | | ChA | 6 | Oak | 4 | Dotson | McCatty | Farmer | Squires |
| 5/25/1981 | | | Min | 2 | Tex | 3 | Medich | Williams | Comer | Putnam |
| 5/25/1981 | | | Pit | 11 | ChN | 1 | Rhoden | Martz | | Garner |
| 5/25/1981 | | | StL | 1 | Mon | 4 | Gullickson | Sorensen | Sosa | Speier |
| 5/25/1981 | | | Phi | 2 | NYN | 5 | Harris | Ruthven | Allen | Kingman |
| 5/25/1981 | | | LA | 5 | Atl | 6 | Camp | Howe | | Benedict |
| 5/25/1981 | | 11 | SF | 5 | Cin | 4 | Breining | Combe | Lavelle | Cabell |
| 5/25/1981 | | | SD | 2 | Hou | 1 | Mura | Niekro | Lucas | Jones |
| 5/25/1981 | 1 | | KC | 3 | Sea | 2 | Gura | Allard | Quisenberry | White |
| 5/25/1981 | 2 | | KC | 1 | Sea | 14 | Gleaton | Berenguer | | Gray |
| 5/26/1981 | | | NYA | 11 | Bal | 5 | Nelson | McGregor | LaRoche | Piniella |
| 5/26/1981 | | | Cle | 2 | Bos | 7 | Eckersley | Garland | | Yastrzemski |
| 5/26/1981 | | | Det | 4 | Mil | 9 | Keeton | Wilcox | Fingers | Thomas |
| 5/26/1981 | | | Tor | 0 | Cal | 2 | Rau | Leal | | Baylor |
| 5/26/1981 | | | ChA | 4 | Oak | 3 | Burns | McLaughlin | Farmer | LeFlore |
| 5/26/1981 | | | KC | 3 | Sea | 2 | Leonard | Abbott | | White |
| 5/26/1981 | | | Min | 5 | Tex | 1 | Redfern | Jenkins | | Ward |
| 5/26/1981 | | | Pit | 3 | ChN | 0 | Camacho | Smith | | Lacy |
| 5/26/1981 | | | StL | 5 | Mon | 6 | Rogers | Martinez | Fryman | Cromartie |
| 5/26/1981 | | | Phi | 7 | NYN | 4 | Carlton | Jones | McGraw | |
| 5/26/1981 | | | SD | 0 | Hou | 1 | Ryan | Eichelberger | Smith,D | Cedeno |
| 5/27/1981 | | | NYA | 1 | Bal | 7 | Flanagan | May | | Singleton |
| 5/27/1981 | | | Cle | 8 | Bos | 4 | Blyleven | Tudor | | Thornton |
| 5/27/1981 | | | Det | 0 | Mil | 4 | Lerch | Bailey | | Oglivie |
| 5/27/1981 | | | Tor | 0 | Cal | 5 | Forsch | Stieb | | Burleson |
| 5/27/1981 | | | ChA | 3 | Oak | 4 | Heaverlo | Farmer | Owchinko | Johnson |
| 5/27/1981 | | | KC | 7 | Sea | 2 | Splittorff | Bannister | | Brett,G |
| 5/27/1981 | | | Min | 2 | Tex | 3 | Darwin | Koosman | Comer | Stein |
| 5/27/1981 | | 11 | Pit | 2 | ChN | 1 | Romo | Capilla | | Thompson |
| 5/27/1981 | | 11 | StL | 4 | Mon | 5 | Bahnsen | Sutter | | Parrish |
| 5/27/1981 | | | Phi | 0 | NYN | 6 | Zachry | Christenson | | Kingman |
| 5/27/1981 | | | LA | 2 | Atl | 4 | Boggs | Reuss | Camp | Linares |
| 5/27/1981 | | | SF | 8 | Cin | 10 | Combe | Minton | Bair | Driessen |
| 5/27/1981 | | | SD | 6 | Hou | 0 | Welsh | Knepper | | Richards |
| 5/28/1981 | | | Det | 0 | Mil | 2 | Caldwell | Petry | Fingers | Gantner |
| 5/28/1981 | | | Min | 0 | Tex | 4 | Honeycutt | Erickson | | Sundberg |
| 5/28/1981 | | | Pit | 10 | ChN | 4 | Solomon | Caudill | | Solomon |
| 5/28/1981 | | | LA | 9 | Atl | 5 | Valenzuela | Perry | Stewart | Scioscia |
| 5/28/1981 | | | SF | 8 | Cin | 2 | Whitson | Berenyi | Holland | Herndon |
| 5/29/1981 | | | Det | 0 | Bal | 4 | Martinez,D | Schatzeder | | Roenicke |
| 5/29/1981 | | | Mil | 0 | Bos | 10 | Torrez | Slaton | | Yastrzemski |
| 5/29/1981 | | | NYA | 8 | Cle | 0 | Righetti | Waits | | Mumphrey |
| 5/29/1981 | | | Oak | 2 | Tor | 4 | Clancy | Keough | McLaughlin | Velez |
| 5/29/1981 | | | KC | 2 | Min | 7 | Arroyo | Gale | | Mackanin |
| 5/29/1981 | | | Sea | 5 | Tex | 4 | Galasso | Matlack | Rawley | Anderson,J |
| 5/29/1981 | | 12 | Pit | 2 | Mon | 3 | Reardon | Tekulve | | Raines |
| 5/29/1981 | | | ChN | 3 | NYN | 9 | Scott | Martz | | Mazzilli |
| 5/29/1981 | | | StL | 11 | Phi | 2 | Forsch | Espinosa | | Brummer |
| 5/29/1981 | | | Cin | 0 | LA | 1 | Welch | LaCoss | Stewart | Welch |
| 5/29/1981 | | | Atl | 6 | SD | 2 | Niekro | Urrea | | Chambliss |
| 5/29/1981 | | | Hou | 3 | SF | 0 | Sutton | Blue | | |
| 5/30/1981 | | | Det | 5 | Bal | 3 | Morris | Palmer | Saucier | Gibson |
| 5/30/1981 | | | Mil | 0 | Bos | 1 | Tanana | Haas | Clear | Stapleton |
| 5/30/1981 | | 10 | NYA | 7 | Cle | 5 | Davis | Monge | Gossage | Foote |
| 5/30/1981 | | | Oak | 7 | Tor | 3 | Norris | Bomback | | Armas |
| 5/30/1981 | | | Cal | 8 | ChA | 3 | Zahn | Dotson | | Grich |
| 5/30/1981 | | | KC | 9 | Min | 0 | Gura | Williams | | White |
| 5/30/1981 | | | Sea | 2 | Tex | 5 | Medich | Parrott | | Oliver |
| 5/30/1981 | | | Pit | 14 | Mon | 5 | Rhoden | Gullickson | | Parker |
| 5/30/1981 | | | ChN | 8 | NYN | 7 | Krukow | Harris | Kravec | Morales |
| 5/30/1981 | | | StL | 7 | Phi | 5 | Sorensen | Ruthven | Sutter | Hendrick |
| 5/30/1981 | | | Cin | 2 | LA | 1 | Hume | Stewart | Moskau | Nolan |
| 5/30/1981 | | | Atl | 0 | SD | 13 | Mura | Hanna | | Perkins |
| 5/30/1981 | | | Hou | 5 | SF | 3 | Niekro | Ripley | Smith,D | Heep |
| 5/31/1981 | | | Det | 1 | Bal | 6 | McGregor | Cappuzzello | | Dempsey |
| 5/31/1981 | | | Mil | 7 | Bos | 6 | Cleveland | Crawford | | Brouhard |
| 5/31/1981 | | | NYA | 3 | Cle | 2 | May | Barker | Gossage | |
| 5/31/1981 | | | Oak | 9 | Tor | 7 | Jones | Barlow | Owchinko | McKay |
| 5/31/1981 | | | KC | 3 | Min | 1 | Leonard | Redfern | Quisenberry | Aikens |
| 5/31/1981 | | | Sea | 5 | Tex | 10 | Hough | Clay | | Wagner |
| 5/31/1981 | | | Pit | 4 | Mon | 2 | Perez | Rogers | Romo | |
| 5/31/1981 | | | ChN | 5 | NYN | 0 | Reuschel | Jones | Smith | Morales |
| 5/31/1981 | | | StL | 0 | Phi | 3 | Carlton | Martinez | | Boone |
| 5/31/1981 | | | Cin | 5 | LA | 2 | Soto | Reuss | | Driessen |
| 5/31/1981 | | 12 | Atl | 5 | SD | 3 | Camp | Curtis | Hrabosky | Chambliss |
| 5/31/1981 | | | Hou | 2 | SF | 10 | Griffin | Ryan | | LeMaster |
| 5/31/1981 | 1 | | Cal | 6 | ChA | 18 | Hickey | Witt | Hoyt | Lemon |
| 5/31/1981 | 2 | | Cal | 4 | ChA | 5 | Burns | Renko | Hoyt | Nordhagen |
| 6/1/1981 | | 11 | NYA | 18 | Cle | 9 | Castro | Denny | | Winfield |
| 6/1/1981 | | | Mil | 1 | Det | 2 | Wilcox | Easterly | | Brookens |
| 6/1/1981 | | | Cal | 4 | Tor | 1 | Forsch | Stieb | | Carew |
| 6/1/1981 | | | Sea | 4 | KC | 2 | Abbott | Splittorff | Andersen,L | Burroughs |
| 6/1/1981 | | | NYN | 2 | Phi | 0 | Miller | McGraw | Lynch | Brooks |
| 6/1/1981 | | | Mon | 13 | StL | 2 | Lea | Martin | | Cromartie |
| 6/1/1981 | | | Atl | 4 | LA | 2 | Boggs | Howe | Montefusco | Royster |
| 6/1/1981 | | | Cin | 10 | SF | 0 | Berenyi | Alexander | | Oester |
| 6/2/1981 | | | Bos | 6 | Cle | 3 | Eckersley | Blyleven | Burgmeier | Stapleton |
| 6/2/1981 | | | Mil | 0 | Det | 4 | Petry | Caldwell | | Wockenfuss |
| 6/2/1981 | | | Bal | 0 | NYA | 1 | Guidry | Flanagan | LaRoche | Piniella |
| 6/2/1981 | | | Cal | 5 | Tor | 3 | Frost | Leal | Aase | Carew |
| 6/2/1981 | | | Oak | 4 | ChA | 1 | McCatty | Baumgarten | | Armas |
| 6/2/1981 | | | Sea | 4 | KC | 2 | Bannister | Berenguer | Andersen,L | Gray |
| 6/2/1981 | | 10 | Tex | 10 | Min | 6 | Kern | O'Connor | | Sundberg |
| 6/2/1981 | | | NYN | 7 | Phi | 3 | Scott | Espinosa | Lynch | Mazzilli |
| 6/2/1981 | | | ChN | 4 | Pit | 6 | Jackson | Capilla | Scurry | Bevacqua |
| 6/2/1981 | | | Mon | 5 | StL | 0 | Burris | Shirley | | Dawson |
| 6/2/1981 | | | Atl | 2 | LA | 5 | Welch | Perry | Stewart | Baker |
| 6/2/1981 | | | Hou | 2 | SD | 1 | Smith,D | Boone | | Howe |
| 6/2/1981 | | | Cin | 1 | SF | 4 | Whitson | LaCoss | Minton | |
| 6/3/1981 | | | Bos | 10 | Cle | 3 | Tudor | Waits | | Rice |
| 6/3/1981 | | | Mil | 3 | Det | 6 | Schatzeder | Slaton | Saucier | Wockenfuss |
| 6/3/1981 | | | Bal | 1 | NYA | 8 | Righetti | Martinez,D | | Jackson |
| 6/3/1981 | | | Cal | 7 | Tor | 6 | Zahn | Clancy | Jefferson | Beniquez |
| 6/3/1981 | | | Oak | 1 | ChA | 7 | Barrios | Kingman | | Morrison |
| 6/3/1981 | | 12 | Sea | 5 | KC | 3 | Galasso | Martin | | Paciorek |
| 6/3/1981 | | | Tex | 7 | Min | 4 | Honeycutt | Erickson | Comer | |
| 6/3/1981 | | | NYN | 6 | Phi | 1 | Miller | Ruthven | | Staub |
| 6/3/1981 | | | ChN | 1 | Pit | 3 | Bibby | Martz | Romo | Garner |
| 6/3/1981 | | | Mon | 10 | StL | 3 | Bahnsen | Forsch | | Speier |
| 6/3/1981 | | | Atl | 2 | LA | 6 | Hooton | Bradford | | Cey |
| 6/3/1981 | | | Hou | 3 | SD | 2 | Sutton | Wise | Sambito | Walling |
| 6/3/1981 | | | Cin | 3 | SF | 2 | Pastore | Blue | Combe | Driessen |
| 6/4/1981 | | | Bos | 4 | Cle | 2 | Torrez | Spillner | Clear | Rice |
| 6/4/1981 | | | Bal | 5 | NYA | 7 | Nelson | Ford | LaRoche | |
| 6/4/1981 | | 11 | Oak | 4 | ChA | 5 | Lamp | Kingman | | LeFlore |
| 6/4/1981 | | | Tex | 6 | Min | 3 | Matlack | Arroyo | Comer | Oliver |
| 6/4/1981 | | | ChN | 2 | Pit | 4 | Rhoden | Krukow | Romo | Nicosia |
| 6/4/1981 | | | Mon | 6 | StL | 7 | Sorensen | Lee | Kaat | Hendrick |
| 6/4/1981 | | | Hou | 3 | SD | 2 | Niekro | Mura | Smith,D | Cruz |
| 6/5/1981 | | | Min | 7 | Det | 0 | Havens | Morris | | Mackanin |
| 6/5/1981 | | | ChA | 2 | NYA | 3 | May | Burns | Gossage | Piniella |
| 6/5/1981 | | | Bal | 7 | Cal | 2 | McGregor | Witt | | Singleton |
| 6/5/1981 | | | Mil | 1 | KC | 2 | Martin | Keeton | | Grote |
| 6/5/1981 | | | Bos | 5 | Oak | 4 | Tanana | Keough | | Evans |
| 6/5/1981 | | | Cle | 8 | Sea | 2 | Barker | Parrott | | Hargrove |
| 6/5/1981 | | | Tor | 2 | Tex | 4 | Medich | Bomback | Comer | Rivers |
| 6/5/1981 | | | LA | 3 | ChN | 0 | Reuss | Reuschel | | Landreaux |
| 6/5/1981 | | | SF | 6 | Pit | 4 | Breining | Tekulve | Minton | Cabell |
| 6/5/1981 | | 13 | SD | 3 | StL | 4 | Otten | Armstrong | | Templeton |
| 6/5/1981 | | | Phi | 4 | Atl | 12 | Montefusco | Carlton | | Linares |
| 6/5/1981 | | 12 | Mon | 6 | Cin | 3 | Reardon | Price | Sanderson | Scott |
| 6/5/1981 | | | NYN | 2 | Hou | 7 | Ryan | Jones | | Cedeno |
| 6/6/1981 | | | Min | 1 | Det | 4 | Petry | Redfern | | Summers |
| 6/6/1981 | | | ChA | 5 | NYA | 2 | Trout | Bird | Hoyt | Morrison |
| 6/6/1981 | | | Bal | 1 | Cal | 0 | Flanagan | Forsch | Stoddard | Murray |
| 6/6/1981 | | | Mil | 2 | KC | 3 | Leonard | Vuckovich | Martin | White |
| 6/6/1981 | | | Bos | 5 | Oak | 6 | Norris | Crawford | Minetto | Page |
| 6/6/1981 | | 10 | Cle | 6 | Sea | 5 | Monge | Stein | | Charboneau |
| 6/6/1981 | | | Tor | 0 | Tex | 4 | Jenkins | Stieb | | Bell |
| 6/6/1981 | | | LA | 4 | ChN | 3 | Goltz | Capilla | Stewart | |
| 6/6/1981 | | | SF | 0 | Pit | 3 | Robinson,D | Griffin | Romo | Easler |
| 6/6/1981 | | | SD | 0 | StL | 8 | Martin | Lollar | | Landrum |
| 6/6/1981 | | | Phi | 10 | Atl | 5 | Christenson | Bradford | Reed,R | Schmidt |
| 6/6/1981 | | 11 | Mon | 6 | Cin | 5 | Fryman | Moskau | | Dawson |
| 6/6/1981 | | | NYN | 2 | Hou | 6 | Ruhle | Zachry | | Ruhle |
| 6/7/1981 | | | Min | 0 | Det | 1 | Wilcox | Koosman | | Brookens |
| 6/7/1981 | | | ChA | 8 | NYA | 3 | Baumgarten | Guidry | | Lemon |
| 6/7/1981 | | | Bal | 6 | Cal | 7 | Sanchez | Luebber | Aase | Ott |
| 6/7/1981 | | | Mil | 7 | KC | 5 | Cleveland | Splittorff | Fingers | Moore,C |
| 6/7/1981 | | | Bos | 1 | Oak | 11 | Underwood | Eckersley | | Gross |
| 6/7/1981 | | | Cle | 5 | Sea | 9 | Abbott | Waits | | Gray |
| 6/7/1981 | | | Tor | 0 | Tex | 2 | Darwin | Todd | Comer | Oliver |
| 6/7/1981 | | | LA | 3 | ChN | 1 | Welch | Martz | Stewart | Thomas |
| 6/7/1981 | | | SF | 7 | Pit | 1 | Blue | Solomon | | |
| 6/7/1981 | | | SD | 1 | StL | 0 | Welsh | Shirley | Boone | |
| 6/7/1981 | | | Phi | 4 | Atl | 6 | Perry | Espinosa | Camp | Perry |
| 6/7/1981 | | | Mon | 3 | Cin | 7 | Berenyi | Burris | LaCoss | Driessen |
| 6/7/1981 | | 13 | NYN | 2 | Hou | 4 | Sprowl | Hausman | | Walling |
| 6/8/1981 | | | Cle | 0 | Cal | 13 | Zahn | Spillner | | Ford |
| 6/8/1981 | | | Tor | 1 | ChA | 4 | Lamp | Clancy | Hoyt | Luzinski |
| 6/8/1981 | | | NYA | 8 | KC | 3 | Davis | Gale | | Nettles |
| 6/8/1981 | | | Mil | 9 | Min | 0 | Caldwell | Erickson | | Cooper |
| 6/8/1981 | | | Bos | 5 | Sea | 6 | Galasso | Clear | Andersen,L | Burroughs |
| 6/8/1981 | | | Det | 2 | Tex | 3 | Kern | Lopez | Hough | Putnam |
| 6/8/1981 | | | Hou | 1 | Phi | 0 | Sutton | Ruthven | | Scott |
| 6/9/1981 | | | Cle | 2 | Cal | 11 | Witt | Barker | Aase | |
| 6/9/1981 | | | Tor | 2 | ChA | 13 | Dotson | Leal | | Luzinski |
| 6/9/1981 | | | NYA | 1 | KC | 6 | Berenguer | Nelson | | Grote |
| 6/9/1981 | | | Mil | 9 | Min | 4 | Slaton | Arroyo | Fingers | Oglivie |
| 6/9/1981 | | | Bos | 4 | Sea | 3 | Torrez | Stein | Clear | Lansford |
| 6/9/1981 | | | Det | 7 | Tex | 5 | Lopez | Matlack | Saucier | Kemp |
| 6/9/1981 | | | SF | 0 | ChN | 4 | Krukow | Ripley | | |
| 6/9/1981 | | | Atl | 2 | Mon | 1 | Bradford | Sanderson | Camp | Murphy |
| 6/9/1981 | | | Cin | 5 | NYN | 0 | Pastore | Harris | | Nolan |
| 6/9/1981 | | | Hou | 4 | Phi | 2 | Niekro | Bystrom | Smith,D | Cruz |
| 6/9/1981 | | | SD | 6 | Pit | 2 | Urrea | Scurry | | Perkins |
| 6/9/1981 | | | LA | 3 | StL | 9 | Forsch | Forster | | Lezcano |
| 6/9/1981 | 1 | | Bal | 0 | Oak | 2 | McCatty | Palmer | | Armas |
| 6/9/1981 | 2 | | Bal | 1 | Oak | 5 | Kingman | McGregor | Jones | Armas |
| 6/10/1981 | | | Tex | 3 | Mil | 1 | Medich | Haas | Comer | Roberts |
| 6/10/1981 | | | KC | 4 | Tor | 1 | Leonard | Bomback | Quisenberry | Wilson |
| 6/10/1981 | | | Cle | 9 | Cal | 11 | Sanchez | Blyleven | | Ford |
| 6/10/1981 | | 13 | NYA | 2 | ChA | 1 | LaRoche | Robinson | Davis | Winfield |
| 6/10/1981 | | | Det | 0 | Min | 2 | Havens | Morris | | Wilfong |
| 6/10/1981 | | | Bal | 9 | Oak | 3 | Flanagan | Langford | | Murray |
| 6/10/1981 | | | Bos | 2 | Sea | 5 | Allard | Tanana | Rawley | Cruz |
| 6/10/1981 | | | SF | 3 | ChN | 1 | Alexander | Reuschel | Minton | Martin |
| 6/10/1981 | | | Atl | 6 | Mon | 3 | Camp | Gullickson | Hanna | Porter |
| 6/10/1981 | | | Cin | 6 | NYN | 2 | Soto | Jones | | Driessen |
| 6/10/1981 | | | Hou | 3 | Phi | 7 | Carlton | Ryan | McGraw | Boone |
| 6/10/1981 | | | SD | 2 | Pit | 18 | Perez | Eichelberger | | Berra |
| 6/10/1981 | | | LA | 10 | StL | 2 | Reuss | Sorensen | | Baker |
| 6/11/1981 | | | Tex | 2 | Mil | 4 | Vuckovich | Jenkins | Fingers | Yount |
| 6/11/1981 | | | KC | 4 | Tor | 1 | Splittorff | Stieb | Quisenberry | Brett,G |
| 6/11/1981 | | 11 | Bos | 4 | Cal | 5 | Forsch | Stanley | | Burleson |
| 6/11/1981 | | | NYA | 2 | ChA | 4 | Trout | Bird | Farmer | Lemon |
| 6/11/1981 | | | Det | 13 | Min | 5 | Petry | Redfern | | Summers |
| 6/11/1981 | | | Bal | 9 | Sea | 12 | Galasso | Stoddard | | Burroughs |
| 6/11/1981 | | | SF | 2 | ChN | 0 | Griffin | Martz | Minton | Herndon |
| 6/11/1981 | | | Atl | 4 | Mon | 12 | Rogers | Boggs | Lee | Raines |
| 6/11/1981 | | 10 | Cin | 5 | NYN | 6 | Falcone | Moskau | | Trevino |
| 6/11/1981 | | | LA | 8 | StL | 0 | Valenzuela | Martinez | | Cey |
| 8/10/1981 | | | KC | 2 | Bal | 3 | Martinez,D | Leonard | Martinez,T | Singleton |
| 8/10/1981 | | | ChA | 4 | Bos | 6 | Eckersley | Dotson | Burgmeier | Rice |
| 8/10/1981 | | | Mil | 4 | Cle | 2 | Easterly | Monge | Fingers | Cooper |
| 8/10/1981 | | | Tor | 3 | Det | 7 | Wilcox | Clancy | | Summers |
| 8/10/1981 | | | Tex | 3 | NYA | 6 | John | Darwin | Gossage | Revering |
| 8/10/1981 | | | Oak | 7 | Min | 5 | Langford | Erickson | Jones | Hosley |
| 8/10/1981 | | | Cal | 13 | Sea | 5 | Zahn | Abbott | Aase | Baylor |
| 8/10/1981 | | 11 | NYN | 2 | ChN | 1 | Allen | Smith | | Valentine |
| 8/10/1981 | | | Pit | 0 | Mon | 8 | Sanderson | Bibby | | Dawson |
| 8/10/1981 | | | StL | 11 | Phi | 8 | Sykes | Noles | Sutter | Oberkfell |
| 8/10/1981 | | | Cin | 2 | LA | 0 | Pastore | Reuss | | Collins |
| 8/10/1981 | | | Atl | 2 | SD | 1 | Niekro | Eichelberger | Camp | |
| 8/10/1981 | | | Hou | 8 | SF | 4 | Sutton | Minton | | Reynolds |
| 8/11/1981 | | | ChA | 12 | Bos | 9 | Farmer | Stanley | Hoyt | Squires |
| 8/11/1981 | | | Tor | 1 | Det | 5 | Schatzeder | Mirabella | Saucier | Parrish |
| 8/11/1981 | | 10 | Tex | 3 | NYA | 2 | Comer | Davis | | Oliver |
| 8/11/1981 | | | Oak | 15 | Min | 3 | Norris | Williams | | Gross |
| 8/11/1981 | | | Cal | 5 | Sea | 2 | Forsch | Rawley | Aase | Lynn |
| 8/11/1981 | | | NYN | 8 | ChN | 4 | Zachry | Martz | | Kingman |
| 8/11/1981 | | | Pit | 2 | Mon | 5 | Gullickson | Rhoden | Reardon | Carter |
| 8/11/1981 | | | StL | 13 | Phi | 4 | Sorensen | Espinosa | | Herr |
| 8/11/1981 | | 12 | Cin | 0 | LA | 1 | Howe | Price | | Ferguson |
| 8/11/1981 | | | Atl | 1 | SD | 8 | Mura | Perry | | Richards |
| 8/11/1981 | | | Hou | 4 | SF | 2 | Niekro | Griffin | Sambito | Puhl |
| 8/11/1981 | 1 | | Mil | 7 | Cle | 8 | Stanton | Cleveland | Monge | Orta |
| 8/11/1981 | 2 | | Mil | 2 | Cle | 5 | Waits | Slaton | Spillner | Hassey |
| 8/12/1981 | | | ChA | 3 | Bos | 4 | Burgmeier | Hickey | | Perez |
| 8/12/1981 | | 10 | Mil | 6 | Cle | 5 | Fingers | Monge | | Bosley |
| 8/12/1981 | | | Tor | 1 | Det | 4 | Morris | Stieb | | Parrish |
| 8/12/1981 | | 15 | Tex | 5 | NYA | 3 | Hough | Frazier | Babcock | Oliver |
| 8/12/1981 | | | Oak | 5 | Min | 1 | Keough | Redfern | | Gross |
| 8/12/1981 | | | Cal | 1 | Sea | 2 | Clay | Frost | Andersen,L | Randle |
| 8/12/1981 | | 10 | NYN | 5 | ChN | 3 | Allen | McGlothen | Falcone | Wilson |
| 8/12/1981 | | | StL | 3 | Phi | 2 | Martinez | Ruthven | Sutter | |
| 8/12/1981 | | | Mon | 6 | Pit | 5 | Lee | Scurry | Reardon | Carter |
| 8/12/1981 | | | Cin | 1 | LA | 3 | Welch | Seaver | Howe | Cey |
| 8/12/1981 | | | Atl | 2 | SD | 3 | Lucas | Bradford | | Kennedy |
| 8/12/1981 | | | Hou | 0 | SF | 2 | Blue | Ruhle | Minton | Cabell |
| 8/12/1981 | 1 | | KC | 9 | Bal | 7 | Martin | Schneider | Quisenberry | Motley |
| 8/12/1981 | 2 | | KC | 9 | Bal | 4 | Wright | McGregor | | Otis |
| 8/13/1981 | | | KC | 7 | Bal | 3 | Gale | Flanagan | | Washington |
| 8/13/1981 | | | ChA | 8 | Bos | 19 | Burgmeier | Patterson | | Miller |
| 8/13/1981 | | | Mil | 4 | Cle | 11 | Garland | Haas | Stanton | Manning |
| 8/13/1981 | | | NYA | 1 | Det | 0 | Guidry | Petry | | Milbourne |
| 8/13/1981 | | | Sea | 5 | Min | 4 | Rawley | Corbett | | Randle |
| 8/13/1981 | | | NYN | 10 | ChN | 0 | Harris | Bird | | Youngblood |
| 8/13/1981 | | | StL | 2 | Phi | 4 | Carlton | Martin | Reed,R | Maddox |
| 8/13/1981 | | | Mon | 3 | Pit | 4 | Romo | Lee | | Lacy |
| 8/13/1981 | | | Atl | 1 | LA | 5 | Hooton | Boggs | | Garvey |
| 8/13/1981 | | 14 | Hou | 5 | SD | 3 | LaCorte | Curtis | | Thon |
| 8/14/1981 | | | ChA | 7 | Bal | 6 | Dotson | Stoddard | Patterson | Nordhagen |
| 8/14/1981 | | | KC | 2 | Cle | 1 | Jones | Blyleven | Quisenberry | White |
| 8/14/1981 | | | NYA | 3 | Det | 1 | May | Wilcox | Frazier | Milbourne |
| 8/14/1981 | | 15 | Mil | 1 | Tor | 4 | Bomback | Augustine | | Mayberry |
| 8/14/1981 | | | Cal | 4 | Oak | 3 | Renko | McCatty | Hassler | Ford |
| 8/14/1981 | | | Bos | 2 | Tex | 4 | Medich | Tanana | Comer | Oliver |
| 8/14/1981 | | 11 | StL | 3 | Mon | 1 | Kaat | Fryman | | Tenace |
| 8/14/1981 | | 15 | Phi | 3 | NYN | 4 | Allen | Reed,R | | Brooks |
| 8/14/1981 | | | Atl | 3 | LA | 4 | Stewart | Camp | | Smith |
| 8/14/1981 | | | Hou | 4 | SD | 6 | Lucas | Ryan | Boone | Turner |
| 8/14/1981 | 1 | | Sea | 8 | Min | 9 | Corbett | Stein | | Baker |
| 8/14/1981 | 1 | 10 | SF | 3 | Cin | 2 | Minton | Hume | | Smith |
| 8/14/1981 | 2 | | Sea | 10 | Min | 7 | Gleaton | Erickson | | Bulling |
| 8/14/1981 | 2 | | SF | 10 | Cin | 7 | Holland | LaCoss | | Morgan |
| 8/15/1981 | | | ChA | 4 | Bal | 7 | Martinez,T | McGlothen | | Singleton |
| 8/15/1981 | | | KC | 2 | Cle | 5 | Denny | Leonard | Spillner | Hargrove |
| 8/15/1981 | | | NYA | 6 | Det | 2 | LaRoche | Schatzeder | | Watson |
| 8/15/1981 | | | Mil | 3 | Tor | 4 | Bomback | Slaton | | Wells |
| 8/15/1981 | | | Sea | 5 | Min | 0 | Abbott | Havens | | Zisk |
| 8/15/1981 | | | Cal | 2 | Oak | 0 | Zahn | Kingman | | |
| 8/15/1981 | | | Bos | 1 | Tex | 5 | Darwin | Eckersley | | Grubb |
| 8/15/1981 | | | Pit | 6 | ChN | 3 | Bibby | Krukow | Scurry | Milner |
| 8/15/1981 | | | Phi | 0 | NYN | 2 | Leach | Espinosa | Searage | Brooks |
| 8/15/1981 | | | SF | 1 | Cin | 7 | Pastore | Alexander | | Griffey |
| 8/15/1981 | | | Atl | 9 | LA | 1 | Niekro | Reuss | | Chambliss |
| 8/15/1981 | | | Hou | 5 | SD | 3 | Sutton | Boone | Smith,D | Spilman |
| 8/16/1981 | | | ChA | 2 | Bal | 6 | Palmer | Baumgarten | | Ripken |
| 8/16/1981 | | | NYA | 2 | Det | 3 | Morris | Righetti | Saucier | Trammell |
| 8/16/1981 | | | Sea | 14 | Min | 0 | Beattie | Redfern | | Anderson,J |
| 8/16/1981 | | | Cal | 3 | Oak | 4 | Langford | Aase | | |
| 8/16/1981 | | | Bos | 1 | Tex | 16 | Honeycutt | Ojeda | | Oliver |
| 8/16/1981 | | | Phi | 3 | NYN | 5 | Zachry | Ruthven | Boitano | Mazzilli |
| 8/16/1981 | | | SF | 2 | Cin | 8 | Soto | Griffin | | Oester |
| 8/16/1981 | | | Atl | 4 | LA | 2 | Perry | Valenzuela | Camp | Ramirez |
| 8/16/1981 | | | Hou | 5 | SD | 8 | Mura | Niekro | Littlefield | Bass |
| 8/16/1981 | 1 | | KC | 11 | Cle | 7 | Gura | Waits | Brett,K | Brett,G |
| 8/16/1981 | 1 | | Mil | 1 | Tor | 4 | Stieb | Caldwell | Mirabella | Bell |
| 8/16/1981 | 1 | | Pit | 5 | ChN | 2 | Rhoden | Kravec | | Alexander,G |
| 8/16/1981 | 2 | | KC | 1 | Cle | 5 | Barker | Splittorff | Monge | Manning |
| 8/16/1981 | 2 | | Mil | 1 | Tor | 4 | Todd | Lerch | Bomback | Bell |
| 8/16/1981 | 2 | | Pit | 11 | ChN | 6 | Perez | Howell | | Perez |
| 8/17/1981 | | | Min | 4 | Det | 7 | Petry | Koosman | Tobik | Peters |
| 8/17/1981 | | | ChA | 1 | NYA | 4 | Reuschel | Burns | Gossage | Winfield |
| 8/17/1981 | | 10 | Tor | 2 | KC | 5 | Brett,K | Bomback | | Brett,G |
| 8/17/1981 | | | LA | 2 | ChN | 5 | Capilla | Niedenfuer | | Waller |
| 8/17/1981 | | | SF | 10 | Pit | 4 | Blue | Solomon | | Morgan |
| 8/17/1981 | | | SD | 3 | StL | 0 | Wise | Sorensen | Lucas | Kennedy |
| 8/17/1981 | | | Mon | 1 | Hou | 6 | Ruhle | Burris | | Puhl |
| 8/18/1981 | | | Min | 1 | Det | 5 | Wilcox | Erickson | | Kemp |
| 8/18/1981 | | | ChA | 5 | NYA | 2 | Trout | Guidry | | Luzinski |
| 8/18/1981 | | | Bal | 5 | Cal | 4 | McGregor | Frost | Stoddard | Murray |
| 8/18/1981 | | | Tor | 0 | KC | 17 | Jones | Leal | | Brett,G |
| 8/18/1981 | | | Bos | 7 | Oak | 3 | Stanley | Norris | | Evans |
| 8/18/1981 | | | Cle | 7 | Sea | 6 | Stanton | Andersen,L | Spillner | Hassey |
| 8/18/1981 | | | LA | 2 | ChN | 3 | Griffin | Hooton | Capilla | Buckner |
| 8/18/1981 | | | SF | 6 | Pit | 7 | Scurry | Holland | | Foli |
| 8/18/1981 | | | SD | 0 | StL | 3 | Martinez | Welsh | Littell | Hendrick |
| 8/18/1981 | | | NYN | 4 | Atl | 2 | Lynch | Mahler | Allen | Stearns |
| 8/18/1981 | | | Phi | 3 | Cin | 2 | Carlton | Seaver | Reed,R | Schmidt |
| 8/18/1981 | | | Mon | 13 | Hou | 4 | Rogers | Knepper | | Dawson |
| 8/18/1981 | 1 | | Mil | 1 | Tex | 2 | Comer | Easterly | | Poquette |
| 8/18/1981 | 2 | | Mil | 2 | Tex | 6 | Jenkins | Vuckovich | | Putnam |
| 8/19/1981 | | | Min | 3 | Det | 4 | Rozema | Cooper | Saucier | Gibson |
| 8/19/1981 | | | ChA | 1 | NYA | 2 | John | Dotson | Gossage | Jackson |
| 8/19/1981 | | | Bal | 0 | Cal | 4 | Renko | Flanagan | | Grich |
| 8/19/1981 | | | Tor | 0 | KC | 1 | Leonard | Berenguer | Quisenberry | McRae |
| 8/19/1981 | | | Bos | 3 | Oak | 7 | Keough | Tanana | | Johnson |
| 8/19/1981 | | 11 | Cle | 6 | Sea | 4 | Spillner | Andersen,L | | Dybzinski |
| 8/19/1981 | | | Mil | 6 | Tex | 3 | Cleveland | Medich | Fingers | Thomas |
| 8/19/1981 | | | LA | 4 | ChN | 3 | Goltz | Capilla | Howe | Cey |
| 8/19/1981 | | | SF | 5 | Pit | 1 | Alexander | Jones | | May |
| 8/19/1981 | | | SD | 2 | StL | 5 | Martin | Eichelberger | | Martin |
| 8/19/1981 | | 11 | NYN | 5 | Atl | 2 | Marshall | Camp | | Wilson |
| 8/19/1981 | | | Phi | 7 | Cin | 4 | Christenson | Berenyi | McGraw | Maddox |
| 8/19/1981 | | | Mon | 4 | Hou | 6 | Smith,D | Sosa | Sprowl | Scott |
| 8/20/1981 | | 10 | Bal | 6 | Cal | 7 | Kison | Martinez,T | | Baylor |
| 8/20/1981 | | | Bos | 1 | Oak | 5 | McCatty | Eckersley | | Armas |
| 8/20/1981 | | | Cle | 5 | Sea | 4 | Waits | Abbott | Spillner | Hassey |
| 8/20/1981 | | | NYN | 2 | Atl | 4 | Niekro | Harris | | Niekro |
| 8/21/1981 | | | Tex | 3 | Det | 7 | Lopez | Darwin | Tobik | Whitaker |
| 8/21/1981 | | | Min | 2 | Mil | 11 | Caldwell | Williams | | Thomas |
| 8/21/1981 | | | KC | 5 | NYA | 1 | Gura | Righetti | | Washington |
| 8/21/1981 | | | ChA | 5 | Tor | 0 | Baumgarten | Stieb | | Luzinski |
| 8/21/1981 | | | Cle | 3 | Cal | 2 | Barker | Forsch | Spillner | Harrah |
| 8/21/1981 | | | Bal | 15 | Oak | 2 | Palmer | Kingman | Stewart | Singleton |
| 8/21/1981 | | | Bos | 3 | Sea | 2 | Tudor | Parrott | Clear | Stapleton |
| 8/21/1981 | | | SF | 9 | ChN | 7 | Breining | Smith | | Leonard |
| 8/21/1981 | | 13 | Hou | 5 | Phi | 7 | Christenson | Smith,B | | Schmidt |
| 8/21/1981 | | | LA | 0 | StL | 1 | Andujar | Reuss | Sutter | Hendrick |
| 8/21/1981 | | 12 | Mon | 5 | Atl | 6 | Bradford | Sosa | | Benedict |
| 8/21/1981 | | | NYN | 7 | Cin | 5 | Allen | Hume | Boitano | Cubbage |
| 8/21/1981 | 1 | | SD | 3 | Pit | 8 | Rhoden | Mura | | Madlock |
| 8/21/1981 | 2 | | SD | 3 | Pit | 10 | Bibby | Lollar | | Foli |
| 8/22/1981 | | | Tex | 4 | Det | 9 | Petry | Honeycutt | Cappuzzello | Gibson |
| 8/22/1981 | | | Min | 2 | Mil | 9 | Lerch | Redfern | | Cooper |
| 8/22/1981 | | | KC | 11 | NYA | 7 | Splittorff | Reuschel | | Aikens |
| 8/22/1981 | | | ChA | 3 | Tor | 1 | Burns | Clancy | Hoyt | Fisk |
| 8/22/1981 | | | Cle | 3 | Cal | 7 | Witt | Blyleven | | Ford |
| 8/22/1981 | | 10 | Bal | 1 | Oak | 2 | Owchinko | Stoddard | | |
| 8/22/1981 | | | Bos | 3 | Sea | 9 | Beattie | Ojeda | | Paciorek |
| 8/22/1981 | | | SF | 4 | ChN | 0 | Blue | Bird | | Evans |
| 8/22/1981 | | | Hou | 0 | Phi | 1 | Ruthven | Niekro | | Matthews |
| 8/22/1981 | | | SD | 1 | Pit | 5 | Solomon | Wise | | Foli |
| 8/22/1981 | | 11 | LA | 2 | StL | 3 | Martinez | Stewart | | Lezcano |
| 8/22/1981 | | | NYN | 2 | Cin | 10 | Pastore | Falcone | | Foster |
| 8/22/1981 | 1 | | Mon | 10 | Atl | 5 | Burris | Bedrosian | | Scott |
| 8/22/1981 | 2 | | Mon | 7 | Atl | 4 | Bahnsen | Montefusco | Fryman | Dawson |
| 8/23/1981 | | | Tex | 4 | Det | 2 | Matlack | Wilcox | Comer | Grubb |
| 8/23/1981 | | | Min | 4 | Mil | 3 | Arroyo | Fingers | Corbett | Adams |
| 8/23/1981 | | 10 | KC | 4 | NYA | 3 | Quisenberry | Wehrmeister | | Otis |
| 8/23/1981 | | | ChA | 7 | Tor | 4 | McGlothen | Bomback | Hoyt | Squires |
| 8/23/1981 | | 10 | Cle | 3 | Cal | 4 | Aase | Spillner | | Harris |
| 8/23/1981 | | | Bal | 4 | Oak | 5 | Norris | Flanagan | Owchinko | Henderson |
| 8/23/1981 | | | Bos | 9 | Sea | 3 | Torrez | Clay | | Evans |
| 8/23/1981 | | | SF | 4 | ChN | 5 | Tidrow | Holland | | Buckner |
| 8/23/1981 | | | Hou | 4 | Phi | 2 | Knepper | Carlton | Sprowl | Thon |
| 8/23/1981 | | 12 | SD | 6 | Pit | 7 | Tiant | Littlefield | | Easler |
| 8/23/1981 | | 11 | LA | 8 | StL | 10 | Sutter | Pena | | Iorg |
| 8/23/1981 | | | Mon | 6 | Atl | 7 | Mahler | Sosa | | Washington |
| 8/23/1981 | | | NYN | 0 | Cin | 9 | Seaver | Lynch | | Driessen |
| 8/24/1981 | | | KC | 3 | Det | 1 | Jones | Schatzeder | Wright | Wilson |
| 8/24/1981 | | | ChA | 5 | Mil | 6 | Keeton | Farmer | Fingers | Molitor |
| 8/24/1981 | | 10 | Min | 3 | NYA | 1 | Corbett | Wehrmeister | | Hatcher |
| 8/24/1981 | | | Tex | 8 | Tor | 1 | Medich | Berenguer | | Sundberg |
| 8/24/1981 | | | Bos | 1 | Cal | 4 | Renko | Clear | Aase | Grich |
| 8/24/1981 | | 12 | Cle | 3 | Oak | 4 | Kingman | Garland | | Armas |
| 8/24/1981 | | | Bal | 2 | Sea | 6 | Gleaton | Martinez,D | | Anderson,J |
| 8/24/1981 | | | SD | 3 | ChN | 4 | Capilla | Urrea | Tidrow | Blackwell |
| 8/24/1981 | | | Atl | 11 | Phi | 1 | Boggs | Christenson | | Horner |
| 8/24/1981 | | | LA | 3 | Pit | 1 | Hooton | Jones | Howe | Russell |
| 8/24/1981 | | | SF | 4 | StL | 2 | Holland | Kaat | Minton | Leonard |
| 8/24/1981 | | | NYN | 1 | Cin | 4 | Berenyi | Scott | Hume | |
| 8/25/1981 | | | KC | 9 | Det | 2 | Leonard | Morris | Quisenberry | Brett,G |
| 8/25/1981 | | | ChA | 3 | Mil | 5 | Slaton | Lamp | Fingers | Bosley |
| 8/25/1981 | | | Min | 4 | NYA | 3 | Jackson,D | May | Verhoeven | Hrbek |
| 8/25/1981 | | | Tex | 4 | Tor | 5 | Todd | Johnson,JH | | Moseby |
| 8/25/1981 | | | Bos | 6 | Cal | 3 | Eckersley | Zahn | Burgmeier | Rudi |
| 8/25/1981 | | | Cle | 0 | Oak | 5 | McCatty | Barker | | Murphy |
| 8/25/1981 | | | Bal | 3 | Sea | 6 | Abbott | Palmer | Andersen,L | Cruz |
| 8/25/1981 | | | SD | 4 | ChN | 7 | Caudill | Lollar | Tidrow | Buckner |
| 8/25/1981 | | | Cin | 5 | Mon | 4 | Bair | Sanderson | Hume | Oester |
| 8/25/1981 | | | Hou | 3 | NYN | 0 | Ryan | Harris | Smith,D | Ashby |
| 8/25/1981 | | | Atl | 8 | Phi | 6 | Hanna | Davis,M | Bradford | Washington |
| 8/25/1981 | | | LA | 2 | Pit | 5 | Tekulve | Goltz | Tiant | Easler |
| 8/25/1981 | | | SF | 7 | StL | 2 | Griffin | Martin | | Evans |
| 8/26/1981 | | | KC | 2 | Det | 4 | Lopez | Gura | Saucier | Gibson |
| 8/26/1981 | | | Min | 2 | NYA | 6 | Righetti | Williams | Frazier | Nettles |
| 8/26/1981 | | 11 | SD | 8 | ChN | 4 | Boone | Smith | | Jones |
| 8/26/1981 | | | Cin | 0 | Mon | 4 | Gullickson | Soto | | Milner |
| 8/26/1981 | | | Hou | 7 | NYN | 1 | Sutton | Zachry | | |
| 8/26/1981 | | | Atl | 11 | Phi | 2 | Perry | Ruthven | | Murphy |
| 8/26/1981 | | | LA | 6 | Pit | 2 | Reuss | Rhoden | | Garvey |
| 8/26/1981 | | | SF | 12 | StL | 9 | Lavelle | Andujar | | May |
| 8/27/1981 | | | Cal | 3 | Bal | 4 | McGregor | Forsch | Stoddard | DeCinces |
| 8/27/1981 | | | Oak | 1 | Bos | 4 | Tudor | Langford | Clear | Hoffman |
| 8/27/1981 | | 11 | Sea | 1 | Cle | 2 | Spillner | Andersen,L | | Kelly |
| 8/27/1981 | | | Tex | 10 | Mil | 16 | Cleveland | Darwin | | Cooper |
| 8/27/1981 | | 10 | KC | 3 | Tor | 4 | McLaughlin | Martin | | Ainge |
| 8/27/1981 | | | NYA | 9 | ChA | 1 | Reuschel | Burns | | Watson |
| 8/27/1981 | | | Det | 3 | Min | 4 | Redfern | Petry | Verhoeven | Mackanin |
| 8/27/1981 | | | Cin | 3 | Mon | 1 | Pastore | Burris | | Foster |
| 8/27/1981 | | | Hou | 0 | NYN | 5 | Falcone | Niekro | | Taveras |
| 8/27/1981 | | | ChN | 6 | LA | 7 | Valenzuela | Martz | Howe | Baker |
| 8/27/1981 | | | StL | 5 | SD | 3 | Forsch | Wise | Sutter | Hernandez |
| 8/27/1981 | | | Pit | 4 | SF | 2 | Solomon | Blue | Jackson | Madlock |
| 8/28/1981 | | | Cal | 4 | Bal | 1 | Witt | Stone | | Hobson |
| 8/28/1981 | | | Oak | 3 | Bos | 1 | Norris | Ojeda | Owchinko | Murphy |
| 8/28/1981 | | | Sea | 2 | Cle | 3 | Denny | Beattie | | Hayes |
| 8/28/1981 | | | Tex | 2 | Mil | 0 | Honeycutt | Haas | | Rivers |
| 8/28/1981 | | | KC | 6 | Tor | 0 | Gale | Leal | | Aikens |
| 8/28/1981 | | 12 | NYA | 1 | ChA | 2 | McGlothen | Davis | | Nordhagen |
| 8/28/1981 | | | Det | 4 | Min | 13 | Koosman | Rozema | Verhoeven | Laudner |
| 8/28/1981 | | | Atl | 0 | Mon | 2 | Rogers | Mahler | | Milner |
| 8/28/1981 | | | Cin | 0 | NYN | 1 | Marshall | Price | Allen | Bailor |
| 8/28/1981 | | | Phi | 4 | Hou | 0 | Carlton | Knepper | | Schmidt |
| 8/28/1981 | | | ChN | 4 | LA | 5 | Forster | Capilla | | Thomas |
| 8/28/1981 | | | Pit | 3 | SF | 4 | Whitson | Scurry | Ripley | Clark |
| 8/29/1981 | | | Cal | 2 | Bal | 5 | Martinez,D | Zahn | Stoddard | Singleton |
| 8/29/1981 | | | Oak | 4 | Bos | 5 | Burgmeier | Jones | | |
| 8/29/1981 | | | Sea | 4 | Cle | 11 | Waits | Bannister | Monge | Harrah |
| 8/29/1981 | | | Tex | 2 | Mil | 5 | Lerch | Matlack | Fingers | Cooper |
| 8/29/1981 | | | KC | 5 | Tor | 4 | Quisenberry | McLaughlin | Martin | Mulliniks |
| 8/29/1981 | | | NYA | 4 | ChA | 2 | John | Farmer | Gossage | Jackson |
| 8/29/1981 | | | Det | 4 | Min | 0 | Schatzeder | Havens | | Parrish |
| 8/29/1981 | | | Atl | 0 | Mon | 7 | Sanderson | Boggs | | Dawson |
| 8/29/1981 | | | Cin | 8 | NYN | 5 | Hume | Allen | LaCoss | O'Berry |
| 8/29/1981 | | | ChN | 3 | LA | 4 | Stewart | Capilla | | Landreaux |
| 8/29/1981 | | | Pit | 4 | SF | 2 | Tiant | Alexander | Tekulve | Foli |
| 8/29/1981 | 1 | | Phi | 1 | Hou | 4 | Ruhle | Davis,M | Smith,D | Cedeno |
| 8/29/1981 | 1 | | StL | 2 | SD | 5 | Welsh | Sorensen | Lucas | Jones |
| 8/29/1981 | 2 | | Phi | 9 | Hou | 2 | Noles | Smith,B | | Schmidt |
| 8/29/1981 | 2 | | StL | 6 | SD | 7 | Lucas | Littell | | Kennedy |
| 8/30/1981 | | | Cal | 0 | Bal | 1 | Stoddard | Renko | | Dwyer |
| 8/30/1981 | | 14 | Oak | 5 | Bos | 4 | Jones | Clear | Kingman | Armas |
| 8/30/1981 | | | Sea | 7 | Cle | 11 | Barker | Drago | | Manning |
| 8/30/1981 | | | Tex | 3 | Mil | 1 | Medich | Easterly | Comer | Sundberg |
| 8/30/1981 | | | NYA | 3 | ChA | 2 | May | Lamp | Gossage | |
| 8/30/1981 | | | Det | 11 | Min | 2 | Morris | Cooper | | Trammell |
| 8/30/1981 | | | Atl | 3 | Mon | 5 | Reardon | Camp | Fryman | Dawson |
| 8/30/1981 | | | Cin | 3 | NYN | 6 | Leach | Moskau | Searage | Taveras |
| 8/30/1981 | | | Phi | 5 | Hou | 8 | Ryan | Espinosa | Sambito | Cedeno |
| 8/30/1981 | | | ChN | 3 | LA | 8 | Stewart | Capilla | | Yeager |
| 8/30/1981 | | 11 | StL | 2 | SD | 1 | Kaat | Urrea | | Ramsey |
| 8/30/1981 | | | Pit | 3 | SF | 8 | Tufts | Perez | | Bergman |
| 8/31/1981 | | | Sea | 4 | Bal | 3 | Clay | McGregor | Drago | Burroughs |
| 8/31/1981 | | | Cal | 5 | Bos | 7 | Campbell | Frost | Crawford | Remy |
| 8/31/1981 | | | Oak | 2 | Cle | 7 | Blyleven | Langford | Stanton | Veryzer |
| 8/31/1981 | | 10 | Det | 6 | ChA | 4 | Saucier | Farmer | | Gibson |
| 8/31/1981 | | | Mil | 2 | KC | 9 | Leonard | Caldwell | | McRae |
| 8/31/1981 | | | NYA | 8 | Min | 0 | Righetti | Williams | | Nettles |
| 8/31/1981 | | | Tor | 2 | Tex | 0 | Stieb | Jenkins | | Velez |
| 8/31/1981 | | | Phi | 1 | Atl | 4 | Perry | Ruthven | | Murphy |
| 8/31/1981 | | | Mon | 3 | Cin | 2 | Sosa | LaCoss | Reardon | Cromartie |
| 8/31/1981 | | | NYN | 2 | Hou | 5 | Sutton | Marshall | | Howe |
| 8/31/1981 | | | Pit | 11 | LA | 3 | Rhoden | Reuss | | Madlock |
| 8/31/1981 | | | ChN | 5 | SD | 6 | Lucas | Smith | | Edwards |
| 9/1/1981 | | | Sea | 6 | Bal | 5 | Abbott | Ford | Andersen,L | Burroughs |
| 9/1/1981 | | | Cal | 2 | Bos | 3 | Stanley | Forsch | Clear | Evans |
| 9/1/1981 | | | Det | 10 | ChA | 6 | Petry | Burns | Tobik | Jackson |
| 9/1/1981 | | | Mil | 2 | KC | 4 | Gura | Haas | Quisenberry | Motley |
| 9/1/1981 | | | NYA | 2 | Min | 5 | Redfern | Reuschel | Corbett | Laudner |
| 9/1/1981 | | | Tor | 4 | Tex | 2 | Clancy | Darwin | Jackson | Upshaw |
| 9/1/1981 | | | Phi | 3 | Atl | 1 | Reed,R | Mahler | Larson | McBride |
| 9/1/1981 | | | Mon | 1 | Cin | 2 | Pastore | Lea | Hume | Foster |
| 9/1/1981 | | | NYN | 3 | Hou | 1 | Falcone | Niekro | Allen | Staub |
| 9/1/1981 | | 10 | Pit | 4 | LA | 6 | Power | Cruz | | Landreaux |
| 9/1/1981 | | | ChN | 3 | SD | 2 | Geisel | Urrea | Tidrow | |
| 9/1/1981 | | | StL | 2 | SF | 0 | Sutter | Minton | | Hernandez |
| 9/2/1981 | | 10 | Sea | 1 | Bal | 0 | Beattie | Martinez,D | | |
| 9/2/1981 | | 13 | Cal | 5 | Bos | 3 | Mahler | Burgmeier | | Baylor |
| 9/2/1981 | | | Det | 9 | ChA | 2 | Ujdur | Dotson | Rozema | Hebner |
| 9/2/1981 | | | Mil | 2 | KC | 6 | Hammaker | Lerch | Quisenberry | Motley |
| 9/2/1981 | | | NYA | 3 | Min | 2 | Guidry | Jackson,D | Gossage | Nettles |
| 9/2/1981 | | | Tor | 0 | Tex | 4 | Honeycutt | Leal | | Wills |
| 9/2/1981 | | | Phi | 6 | Atl | 2 | Reed,R | Bradford | | Matthews |
| 9/2/1981 | | | Mon | 1 | Cin | 7 | Seaver | Bahnsen | | Driessen |
| 9/2/1981 | | | NYN | 8 | Hou | 4 | Scott | Knepper | | Brooks |
| 9/2/1981 | | | Pit | 3 | LA | 1 | Long | Welch | Scurry | Thompson |
| 9/2/1981 | | | ChN | 7 | SD | 4 | Hernandez | Welsh | Tidrow | Buckner |
| 9/2/1981 | | | StL | 2 | SF | 3 | Breining | Sorensen | | Leonard |
| 9/2/1981 | 1 | 11 | Oak | 5 | Cle | 6 | Spillner | Figueroa | | Manning |
| 9/2/1981 | 2 | 10 | Oak | 0 | Cle | 1 | Lewallyn | Keough | | Kuiper |
| 9/3/1981 | | | Oak | 1 | Bal | 2 | Stewart | McCatty | Stoddard | Singleton |
| 9/3/1981 | | | Sea | 5 | Bos | 8 | Torrez | Bannister | Burgmeier | Perez |
| 9/3/1981 | | | Tor | 3 | ChA | 8 | Trout | Berenguer | Farmer | Luzinski |
| 9/3/1981 | | 11 | NYA | 2 | KC | 1 | Gossage | Martin | LaRoche | Cerone |
| 9/3/1981 | | | Mil | 0 | Min | 2 | Havens | Vuckovich | | Mackanin |
| 9/3/1981 | | | Det | 4 | Tex | 6 | Schmidt | Morris | Comer | Rivers |
| 9/3/1981 | | | Hou | 9 | Mon | 5 | Ruhle | Sanderson | Smith,B | Cruz |
| 9/3/1981 | | | Cin | 13 | Phi | 5 | Berenyi | Davis,M | | Griffey |
| 9/3/1981 | | 12 | StL | 5 | LA | 3 | Littell | Forster | | Ramsey |
| 9/3/1981 | | | Pit | 5 | SD | 2 | Tiant | Eichelberger | Scurry | Lacy |
| 9/3/1981 | | | ChN | 4 | SF | 5 | Ripley | Geisel | | Morgan |
| 9/4/1981 | | | Oak | 1 | Bal | 4 | McGregor | Kingman | Stoddard | Dempsey |
| 9/4/1981 | | | Sea | 6 | Bos | 2 | Stoddard | Tanana | | Gray |
| 9/4/1981 | | | Cal | 5 | Cle | 2 | Zahn | Barker | | Ford |
| 9/4/1981 | | | Tor | 3 | ChA | 0 | Stieb | Lamp | Todd | Whitt |
| 9/4/1981 | | 10 | NYA | 7 | KC | 6 | Frazier | Gale | LaRoche | Brown |
| 9/4/1981 | | | Mil | 9 | Min | 6 | Caldwell | Arroyo | Fingers | Cooper |
| 9/4/1981 | | | Det | 8 | Tex | 1 | Wilcox | Medich | | Parrish |
| 9/4/1981 | | | Hou | 3 | Mon | 1 | Ryan | Gullickson | Smith,D | Ashby |
| 9/4/1981 | | | Atl | 5 | NYN | 2 | Niekro | Harris | Garber | Washington |
| 9/4/1981 | | | Cin | 9 | Phi | 5 | Bair | Brusstar | | Concepcion |
| 9/4/1981 | | | StL | 1 | LA | 2 | Goltz | Martin | Stewart | Garvey |
| 9/4/1981 | | | Pit | 4 | SD | 3 | Scurry | Lucas | | Nicosia |
| 9/4/1981 | | | ChN | 4 | SF | 5 | Griffin | Martz | Minton | Clark |
| 9/5/1981 | | | Oak | 6 | Bal | 1 | Langford | Stone | | Johnson |
| 9/5/1981 | | | Sea | 0 | Bos | 3 | Eckersley | Clay | | Yastrzemski |
| 9/5/1981 | | | Tor | 1 | ChA | 3 | Baumgarten | Clancy | Hickey | Almon |
| 9/5/1981 | | | NYA | 3 | KC | 4 | Gura | Righetti | | Motley |
| 9/5/1981 | | | Mil | 1 | Min | 6 | Williams | Slaton | | Corcoran |
| 9/5/1981 | | | Det | 7 | Tex | 4 | Petry | Jenkins | Lopez | Fahey |
| 9/5/1981 | | 11 | Hou | 3 | Mon | 2 | Smith,B | Sosa | | Garcia |
| 9/5/1981 | | | Atl | 8 | NYN | 3 | Perry | Zachry | | Washington |
| 9/5/1981 | | | Cin | 3 | Phi | 6 | Lyle | Soto | Reed,J | Moreland |
| 9/5/1981 | | | StL | 2 | LA | 4 | Reuss | Andujar | Stewart | Scioscia |
| 9/5/1981 | | | Pit | 4 | SD | 1 | Robinson,D | Urrea | Lee | Alexander,M |
| 9/5/1981 | | | ChN | 4 | SF | 6 | Tufts | Hernandez | Holland | LeMaster |
| 9/5/1981 | 1 | | Cal | 0 | Cle | 3 | Blyleven | Renko | Monge | Hayes |
| 9/5/1981 | 2 | | Cal | 6 | Cle | 1 | Frost | Brennan | | Baylor |
| 9/6/1981 | | | Oak | 6 | Bal | 0 | Figueroa | Martinez,D | | Heath |
| 9/6/1981 | | | Sea | 4 | Bos | 5 | Stanley | Abbott | Clear | Perez |
| 9/6/1981 | | | Cal | 2 | Cle | 5 | Denny | Forsch | Spillner | Hayes |
| 9/6/1981 | | | Tor | 0 | ChA | 2 | Burns | Leal | | Nordhagen |
| 9/6/1981 | | | NYA | 4 | KC | 5 | Quisenberry | Reuschel | | Wathan |
| 9/6/1981 | | | Mil | 4 | Min | 5 | Redfern | Haas | Corbett | Corcoran |
| 9/6/1981 | | | Det | 11 | Tex | 5 | Ujdur | Darwin | | Kemp |
| 9/6/1981 | | | Hou | 6 | Mon | 8 | Lea | Sprowl | Jackson | Cromartie |
| 9/6/1981 | | | Atl | 0 | NYN | 1 | Jones | Mahler | Allen | Taveras |
| 9/6/1981 | | | Cin | 2 | Phi | 8 | Noles | Pastore | | Moreland |
| 9/6/1981 | | 18 | StL | 4 | LA | 2 | Littell | Sutcliffe | LaPoint | Gonzalez |
| 9/6/1981 | | | Pit | 3 | SD | 1 | Solomon | Wise | | Solomon |
| 9/6/1981 | | | ChN | 5 | SF | 2 | Griffin | Blue | | Dillard |
| 9/7/1981 | | | Cle | 3 | Bal | 4 | Palmer | Waits | Martinez,T | Murray |
| 9/7/1981 | | | Bos | 6 | Det | 3 | Ojeda | Morris | Burgmeier | Yastrzemski |
| 9/7/1981 | | 10 | Mil | 5 | NYA | 6 | Davis | McClure | | Nettles |
| 9/7/1981 | | | Sea | 6 | ChA | 1 | Beattie | Dotson | | Serna |
| 9/7/1981 | | | Cal | 2 | KC | 7 | Jones | Witt | Quisenberry | Otis |
| 9/7/1981 | | | Tor | 5 | Min | 1 | Berenguer | Jackson,D | Todd | Bell |
| 9/7/1981 | | | Tex | 5 | Oak | 4 | Honeycutt | Norris | Butcher | |
| 9/7/1981 | | | Mon | 5 | Phi | 7 | Reed,J | Bahnsen | Noles | Bowa |
| 9/7/1981 | | | ChN | 1 | StL | 4 | Sorensen | Bird | Sykes | Hernandez |
| 9/7/1981 | | | Hou | 3 | Atl | 0 | Knepper | Boggs | | Puhl |
| 9/7/1981 | | | SD | 0 | Cin | 5 | Seaver | Welsh | | Bench |
| 9/7/1981 | | | SF | 0 | LA | 10 | Welch | Whitson | | Thomas |
| 9/7/1981 | 1 | | NYN | 9 | Pit | 3 | Scott | Jones | | Stearns |
| 9/7/1981 | 2 | | NYN | 4 | Pit | 5 | Robinson,D | Allen | Scurry | Parker |
| 9/8/1981 | | 21 | Cle | 4 | Bal | 5 | Boddicker | Glynn | | Corey |
| 9/8/1981 | | | Bos | 3 | Det | 9 | Wilcox | Torrez | | Summers |
| 9/8/1981 | | | Sea | 8 | ChA | 5 | Bannister | Trout | Andersen,L | Paciorek |
| 9/8/1981 | | | Cal | 0 | KC | 9 | Leonard | Zahn | | Washington |
| 9/8/1981 | | | Tor | 1 | Min | 5 | Havens | Stieb | | Sofield |
| 9/8/1981 | | 11 | Tex | 5 | Oak | 3 | Hough | McCatty | Comer | Bell |
| 9/8/1981 | | | Mon | 5 | Phi | 2 | Sanderson | Larson | | Dawson |
| 9/8/1981 | | | NYN | 0 | Pit | 12 | Tiant | Lynch | | Thompson |
| 9/8/1981 | | | ChN | 2 | StL | 7 | Martinez | Kravec | | Hendrick |
| 9/8/1981 | | | Hou | 0 | Atl | 5 | McWilliams | Ruhle | | Horner |
| 9/8/1981 | | | SD | 2 | Cin | 9 | Berenyi | Eichelberger | | Driessen |
| 9/8/1981 | | | SF | 4 | LA | 2 | Alexander | Hooton | Minton | May |
| 9/9/1981 | | 10 | Cle | 7 | Bal | 5 | Garland | Stoddard | | Thornton |
| 9/9/1981 | | | Bos | 5 | Det | 4 | Aponte | Lopez | Campbell | Gedman |
| 9/9/1981 | | | Sea | 8 | ChA | 3 | Stoddard | Lamp | | Paciorek |
| 9/9/1981 | | | Cal | 0 | KC | 4 | Gura | Frost | | Motley |
| 9/9/1981 | | | Tor | 2 | Min | 8 | Arroyo | Clancy | | Hrbek |
| 9/9/1981 | | | Tex | 2 | Oak | 0 | Medich | Langford | | Bell |
| 9/9/1981 | | | Mon | 7 | Phi | 18 | Brusstar | Bahnsen | | McBride |
| 9/9/1981 | | | NYN | 2 | Pit | 8 | Perez | Harris | | Foli |
| 9/9/1981 | | | ChN | 1 | StL | 4 | Martin | Krukow | Sutter | |
| 9/9/1981 | | 10 | Hou | 2 | Atl | 3 | Camp | Sambito | | Horner |
| 9/9/1981 | | | SD | 6 | Cin | 2 | Lollar | Leibrandt | | Lollar |
| 9/9/1981 | | 11 | SF | 3 | LA | 4 | Castillo | Breining | | Russell |
| 9/9/1981 | 1 | 10 | Mil | 2 | NYA | 3 | Gossage | Fingers | | Gamble |
| 9/9/1981 | 2 | | Mil | 6 | NYA | 9 | May | Caldwell | Frazier | Mumphrey |
| 9/10/1981 | | | Cle | 0 | Bal | 1 | Stewart | Denny | | Singleton |
| 9/10/1981 | | | ChA | 8 | Mil | 4 | Baumgarten | Slaton | | Fisk |
| 9/10/1981 | | | Sea | 6 | Tor | 9 | Todd | Rawley | McLaughlin | Barfield |
| 9/11/1981 | | | Cle | 6 | Det | 5 | Monge | Rozema | Lewallyn | Kuiper |
| 9/11/1981 | | | Bal | 4 | Mil | 5 | McClure | Martinez,D | | Simmons |
| 9/11/1981 | | | Bos | 1 | NYA | 3 | Righetti | Eckersley | Davis | Mumphrey |
| 9/11/1981 | | | Sea | 8 | Tor | 5 | Clark | Berenguer | Andersen,L | Paciorek |
| 9/11/1981 | | | Tex | 2 | Cal | 10 | Forsch | Darwin | | Carew |
| 9/11/1981 | | | ChA | 5 | Min | 2 | Burns | Williams | Hoyt | Nordhagen |
| 9/11/1981 | | | KC | 0 | Oak | 4 | Keough | Hammaker | | Johnson |
| 9/11/1981 | | | Mon | 9 | ChN | 3 | Burris | Griffin | | Manuel |
| 9/11/1981 | | | Phi | 5 | Pit | 3 | Carlton | Rhoden | McGraw | Moreland |
| 9/11/1981 | | | NYN | 5 | StL | 8 | Forsch | Zachry | Sutter | Ramsey |
| 9/11/1981 | | | SD | 2 | Atl | 12 | Perry | Mura | | Horner |
| 9/11/1981 | | | LA | 9 | Cin | 1 | Reuss | Soto | | Garvey |
| 9/11/1981 | | | SF | 0 | Hou | 2 | Sutton | Blue | Smith,D | |
| 9/12/1981 | | | Cle | 5 | Det | 6 | Saucier | Garland | | Peters |
| 9/12/1981 | | | Bal | 1 | Mil | 4 | Lerch | Palmer | Fingers | |
| 9/12/1981 | | | Bos | 5 | NYA | 4 | Clear | Davis | Burgmeier | Gedman |
| 9/12/1981 | | | Sea | 1 | Tor | 4 | Stieb | Beattie | Todd | Beamon |
| 9/12/1981 | | | Tex | 7 | Cal | 0 | Honeycutt | Zahn | | Wills |
| 9/12/1981 | | | ChA | 5 | Min | 2 | Dotson | O'Connor | Farmer | Luzinski |
| 9/12/1981 | | 13 | KC | 6 | Oak | 7 | Beard | Gale | | Davis |
| 9/12/1981 | | | Mon | 1 | ChN | 0 | Rogers | Bird | Fryman | Dawson |
| 9/12/1981 | | | Phi | 9 | Pit | 8 | Reed,R | Robinson,D | McGraw | Rose |
| 9/12/1981 | | | NYN | 1 | StL | 4 | Sorensen | Scott | Sutter | Hernandez |
| 9/12/1981 | | 10 | SD | 4 | Atl | 5 | Garber | Urrea | | Gomez |
| 9/12/1981 | | | LA | 2 | Cin | 3 | Seaver | Valenzuela | Hume | Foster |
| 9/12/1981 | | | SF | 3 | Hou | 4 | Niekro | Whitson | LaCorte | Cruz |
| 9/13/1981 | | | Cle | 6 | Det | 2 | Spillner | Wilcox | | Diaz |
| 9/13/1981 | | | Bal | 6 | Mil | 9 | Cleveland | Stone | Augustine | Thomas |
| 9/13/1981 | | | Bos | 1 | NYA | 3 | Guidry | Tanana | | Jackson |
| 9/13/1981 | | | Tex | 1 | Cal | 2 | Witt | Jenkins | Aase | Baylor |
| 9/13/1981 | | | ChA | 4 | Min | 3 | Trout | Cooper | Hickey | Bernazard |
| 9/13/1981 | | | KC | 11 | Oak | 3 | Jones | McCatty | | Hurdle |
| 9/13/1981 | | | Mon | 3 | ChN | 1 | Sanderson | Krukow | Reardon | Dawson |
| 9/13/1981 | | | Phi | 9 | Pit | 3 | Davis,M | Jones | Reed,R | Bowa |
| 9/13/1981 | | | NYN | 5 | StL | 9 | Otten | Orosco | | Braun |
| 9/13/1981 | | | SD | 2 | Atl | 6 | McWilliams | Kuhaulua | | Horner |
| 9/13/1981 | | 10 | LA | 7 | Cin | 8 | LaCoss | Sutcliffe | | Knight |
| 9/13/1981 | | | SF | 4 | Hou | 1 | Alexander | Knepper | Minton | Brenly |
| 9/14/1981 | | | Det | 5 | Bos | 3 | Petry | Torrez | Saucier | Whitaker |
| 9/14/1981 | | | NYA | 10 | Mil | 11 | McClure | Gossage | | Hisle |
| 9/14/1981 | | | Min | 4 | Tor | 1 | Havens | Clancy | O'Connor | Corcoran |
| 9/14/1981 | | | KC | 1 | Cal | 0 | Wright | Kison | Martin | Brett,G |
| 9/14/1981 | | 10 | ChA | 2 | Sea | 1 | Lamp | Andersen,L | Farmer | Fisk |
| 9/14/1981 | | | Oak | 0 | Tex | 2 | Medich | Langford | Comer | Bell |
| 9/14/1981 | | | Cin | 0 | Hou | 3 | Ruhle | Berenyi | | Puhl |
| 9/14/1981 | | | LA | 0 | SD | 1 | Welsh | Hooton | | Perkins |
| 9/14/1981 | | | Atl | 1 | SF | 2 | Griffin | Boggs | Minton | Martin |
| 9/15/1981 | | | Bal | 3 | Cle | 0 | Martinez,D | Brennan | Martinez,T | Murray |
| 9/15/1981 | | | NYA | 4 | Mil | 6 | Haas | May | Fingers | |
| 9/15/1981 | | | Min | 1 | Tor | 5 | Leal | Arroyo | McLaughlin | Moseby |
| 9/15/1981 | | | KC | 6 | Cal | 9 | Aase | Brett,K | | Ferguson |
| 9/15/1981 | | | ChA | 1 | Sea | 9 | Stoddard | Koosman | | Zisk |
| 9/15/1981 | | | Oak | 3 | Tex | 9 | Hough | Kingman | | Sundberg |
| 9/15/1981 | | | Pit | 2 | ChN | 5 | Griffin | Scurry | Tidrow | Durham |
| 9/15/1981 | | | Cin | 1 | Hou | 4 | Ryan | Leibrandt | Smith,D | Ryan |
| 9/15/1981 | | | LA | 2 | SD | 3 | Lucas | Howe | | Edwards |
| 9/15/1981 | | | Atl | 4 | SF | 3 | Niekro | Tufts | Camp | Murphy |
| 9/15/1981 | 1 | 11 | StL | 3 | Mon | 4 | Reardon | Otten | | Briggs |
| 9/15/1981 | 2 | | StL | 4 | Mon | 5 | Lee | Littell | Fryman | |
| 9/16/1981 | | | NYA | 4 | Mil | 8 | McClure | Davis | | Romero |
| 9/16/1981 | | | Min | 0 | Tor | 5 | Berenguer | Williams | | Woods |
| 9/16/1981 | | | KC | 2 | Cal | 4 | Zahn | Leonard | Aase | Downing |
| 9/16/1981 | | | ChA | 5 | Sea | 10 | Clay | Burns | | Burroughs |
| 9/16/1981 | | | Oak | 3 | Tex | 2 | Norris | Darwin | | Drumright |
| 9/16/1981 | | 14 | Atl | 6 | LA | 7 | Sutcliffe | Montefusco | | Baker |
| 9/16/1981 | | | Hou | 7 | SD | 5 | Sutton | Lollar | | Sutton |
| 9/16/1981 | | | Cin | 4 | SF | 8 | Breining | Price | Tufts | Bergman |
| 9/16/1981 | 1 | 13 | Det | 7 | Bos | 1 | Saucier | Clear | | Gibson |
| 9/16/1981 | 1 | | StL | 12 | Mon | 1 | Forsch | Burris | | Herr |
| 9/16/1981 | 1 | | Phi | 5 | NYN | 3 | Ruthven | Zachry | McGraw | Boone |
| 9/16/1981 | 2 | | Det | 2 | Bos | 5 | Hurst | Ujdur | Rainey | Yastrzemski |
| 9/16/1981 | 2 | | StL | 5 | Mon | 4 | DeLeon | Lea | Sutter | Hendrick |
| 9/16/1981 | 2 | | Phi | 2 | NYN | 6 | Harris | Carlton | | Bailor |
| 9/17/1981 | | | Det | 5 | Bos | 3 | Wilcox | Campbell | Rothschild | Brookens |
| 9/17/1981 | | | Bal | 4 | Cle | 8 | Barker | McGregor | Monge | Orta |
| 9/17/1981 | | 10 | StL | 4 | Mon | 5 | Reardon | Sykes | | |
| 9/17/1981 | | | Phi | 16 | NYN | 3 | Noles | Scott | Lyle | Matthews |
| 9/17/1981 | | | Atl | 3 | LA | 5 | Niedenfuer | Garber | Stewart | Bradley |
| 9/17/1981 | | | Hou | 3 | SD | 6 | Urrea | LaCorte | Boone | Kennedy |
| 9/17/1981 | | 10 | Cin | 2 | SF | 3 | Tufts | Seaver | | May |
| 9/18/1981 | | | Mil | 1 | Bal | 7 | Flanagan | Vuckovich | Stoddard | Lowenstein |
| 9/18/1981 | | | NYA | 0 | Bos | 4 | Tanana | Reuschel | | Miller |
| 9/18/1981 | | | Det | 4 | Cle | 5 | Denny | Tobik | Monge | Hargrove |
| 9/18/1981 | | | Cal | 1 | Tor | 2 | Stieb | Witt | McLaughlin | Moseby |
| 9/18/1981 | | | Oak | 2 | ChA | 5 | Trout | McCatty | Hoyt | Lemon |
| 9/18/1981 | | | KC | 0 | Sea | 3 | Abbott | Jones | | Henderson |
| 9/18/1981 | | 10 | Min | 3 | Tex | 4 | Comer | Corbett | | Sundberg |
| 9/18/1981 | | | ChN | 0 | Mon | 7 | Sanderson | Bird | | Parrish |
| 9/18/1981 | | | StL | 6 | NYN | 8 | Leach | Otten | Allen | Stearns |
| 9/18/1981 | | | Pit | 6 | Phi | 4 | Rhoden | Brusstar | Romo | Pena |
| 9/18/1981 | | | Cin | 3 | LA | 2 | Pastore | Welch | | Griffey |
| 9/18/1981 | | | Atl | 4 | SD | 2 | McWilliams | Wise | Montefusco | Horner |
| 9/18/1981 | | | Hou | 14 | SF | 1 | Knepper | Alexander | | Cedeno |
| 9/19/1981 | | | Mil | 4 | Bal | 2 | Easterly | Martinez,D | Fingers | Cooper |
| 9/19/1981 | | 11 | NYA | 3 | Bos | 2 | Frazier | Clear | | Robertson |
| 9/19/1981 | | | Det | 3 | Cle | 4 | Blyleven | Petry | Monge | Kuiper |
| 9/19/1981 | | | Cal | 11 | Tor | 3 | Kison | Clancy | | Ott |
| 9/19/1981 | | | Oak | 2 | ChA | 0 | Langford | Lamp | | McKay |
| 9/19/1981 | | | KC | 5 | Sea | 1 | Wright | Beattie | | Brett,G |
| 9/19/1981 | | | Min | 4 | Tex | 9 | Medich | Jackson,D | | Oliver |
| 9/19/1981 | | | ChN | 5 | Mon | 3 | Smith | Jackson | Tidrow | Blackwell |
| 9/19/1981 | | | StL | 6 | NYN | 1 | Martin | Falcone | | Tenace |
| 9/19/1981 | | | Pit | 3 | Phi | 5 | McGraw | Romo | | Schmidt |
| 9/19/1981 | | | Cin | 3 | LA | 1 | Berenyi | Hooton | Hume | Griffey |
| 9/19/1981 | | | Atl | 7 | SD | 12 | Fireovid | Boggs | | Kennedy |
| 9/19/1981 | | | Hou | 9 | SF | 4 | LaCorte | Griffin | | |
| 9/20/1981 | | | Mil | 4 | Bal | 1 | Caldwell | Palmer | Fingers | Simmons |
| 9/20/1981 | | | NYA | 2 | Bos | 4 | Hurst | John | Stanley | Miller |
| 9/20/1981 | | | Det | 8 | Cle | 6 | Morris | Brennan | Lopez | Kemp |
| 9/20/1981 | | | Cal | 5 | Tor | 2 | Zahn | Leal | Aase | Ott |
| 9/20/1981 | | 12 | Oak | 4 | ChA | 5 | Koosman | Owchinko | | Bernazard |
| 9/20/1981 | | | KC | 3 | Sea | 7 | Clark | Leonard | | Paciorek |
| 9/20/1981 | | | Min | 4 | Tex | 5 | Hough | Cooper | | Wills |
| 9/20/1981 | | | ChN | 2 | Mon | 4 | Gullickson | Griffin | Fryman | Carter |
| 9/20/1981 | | | StL | 8 | NYN | 3 | Sorensen | Zachry | | Hendrick |
| 9/20/1981 | | | Pit | 3 | Phi | 1 | Solomon | Proly | Romo | Berra |
| 9/20/1981 | | | Cin | 5 | LA | 2 | Soto | Power | Hume | Foster |
| 9/20/1981 | | | Atl | 6 | SD | 4 | Camp | Kuhaulua | Garber | Hubbard |
| 9/20/1981 | | 12 | Hou | 7 | SF | 8 | Holland | Pladson | | Leonard |
| 9/21/1981 | | | Det | 5 | Bal | 1 | Wilcox | McGregor | | Kemp |
| 9/21/1981 | | | Mil | 5 | Bos | 3 | Bernard | Eckersley | Fingers | Howell |
| 9/21/1981 | | | Cle | 2 | NYA | 4 | May | Waits | Davis | Milbourne |
| 9/21/1981 | | | ChA | 6 | Cal | 1 | Hickey | Aase | | Bernazard |
| 9/21/1981 | | | Min | 3 | KC | 2 | Williams | Hammaker | Corbett | Engle |
| 9/21/1981 | | | Sea | 6 | Tex | 7 | Johnson,JH | Andersen,L | | Jones |
| 9/21/1981 | | | StL | 2 | ChN | 0 | Andujar | Kravec | | |
| 9/21/1981 | | 11 | Phi | 2 | Mon | 3 | Reardon | McGraw | | Mills |
| 9/21/1981 | | | Pit | 3 | NYN | 2 | Tiant | Harris | Scurry | Pena |
| 9/21/1981 | | | Cin | 6 | SD | 4 | Leibrandt | Welsh | Price | Kennedy |
| 9/22/1981 | | | Det | 5 | Bal | 1 | Tobik | Stoddard | | Wockenfuss |
| 9/22/1981 | | | Mil | 0 | Bos | 6 | Ojeda | Vuckovich | | Stapleton |
| 9/22/1981 | | | Cle | 2 | NYA | 1 | Barker | Righetti | Spillner | Charboneau |
| 9/22/1981 | | | ChA | 3 | Cal | 7 | Moreno | Koosman | | Brunansky |
| 9/22/1981 | | | Min | 1 | KC | 2 | Gura | Arroyo | | McRae |
| 9/22/1981 | | | Sea | 4 | Tex | 6 | Butcher | Clay | Johnson,JH | Poquette |
| 9/22/1981 | | | StL | 17 | ChN | 7 | Bair | Bird | | Forsch |
| 9/22/1981 | | | Phi | 14 | Mon | 4 | Ruthven | Rogers | | Matthews |
| 9/22/1981 | | 13 | Pit | 4 | NYN | 1 | Lee | Leach | | Thompson |
| 9/22/1981 | | | Atl | 3 | Hou | 8 | Sutton | Perry | | Heep |
| 9/22/1981 | | | Cin | 4 | SD | 0 | Seaver | Eichelberger | | Foster |
| 9/22/1981 | | | LA | 12 | SF | 4 | Valenzuela | Whitson | | Garvey |
| 9/22/1981 | 1 | | Oak | 0 | Tor | 3 | Stieb | Underwood | | Moseby |
| 9/22/1981 | 2 | | Oak | 7 | Tor | 6 | McLaughlin | Garvin | Jones | Armas |
| 9/23/1981 | | | Det | 7 | Bal | 2 | Petry | Martinez,D | | |
| 9/23/1981 | | | Mil | 4 | Bos | 8 | Burgmeier | Keeton | | Yastrzemski |
| 9/23/1981 | | | Cle | 7 | NYA | 2 | Denny | LaRoche | | Hargrove |
| 9/23/1981 | | | Oak | 7 | Tor | 2 | Langford | McLaughlin | | Stanley |
| 9/23/1981 | | 10 | ChA | 9 | Cal | 10 | Aase | Robinson | | Ford |
| 9/23/1981 | | | Min | 0 | KC | 1 | Jones | Redfern | | White |
| 9/23/1981 | | | Sea | 2 | Tex | 6 | Honeycutt | Abbott | Kern | Roberts |
| 9/23/1981 | | | NYN | 1 | ChN | 5 | Krukow | Lynch | Tidrow | Durham |
| 9/23/1981 | | | Pit | 1 | Mon | 7 | Sanderson | Rhoden | | Speier |
| 9/23/1981 | | | Phi | 7 | StL | 8 | Sutter | Brusstar | | Herr |
| 9/23/1981 | | | Atl | 2 | Hou | 3 | Niekro | Mahler | Sambito | Reynolds |
| 9/23/1981 | | | Cin | 2 | SD | 4 | Wise | Pastore | Lucas | Kennedy |
| 9/23/1981 | | | LA | 3 | SF | 4 | Minton | Niedenfuer | Rowland | Ransom |
| 9/24/1981 | | | Cle | 3 | Bos | 10 | Torrez | Brennan | | Yastrzemski |
| 9/24/1981 | | | Bal | 0 | NYA | 1 | Guidry | Palmer | Gossage | Jackson |
| 9/24/1981 | | | ChA | 2 | Cal | 3 | Kison | Hickey | | Downing |
| 9/24/1981 | | | Min | 5 | KC | 8 | Gale | Havens | | Otis |
| 9/24/1981 | | | Sea | 3 | Tex | 5 | Comer | Rawley | Johnson,JH | Lisi |
| 9/24/1981 | | 10 | NYN | 1 | ChN | 2 | Geisel | Orosco | | Henderson |
| 9/24/1981 | | | Pit | 2 | Mon | 4 | Lee | Tekulve | Reardon | Lee |
| 9/24/1981 | | | Phi | 3 | StL | 4 | Sorensen | Davis,M | Sutter | Landrum |
| 9/24/1981 | | 10 | Atl | 0 | Hou | 1 | Smith,D | Garber | | Heep |
| 9/24/1981 | | | LA | 3 | SF | 0 | Welch | Griffin | | |
| 9/25/1981 | | | Cle | 1 | Bos | 4 | Hurst | Garland | Burgmeier | Evans |
| 9/25/1981 | | | Mil | 7 | Det | 4 | Augustine | Kinney | Fingers | Simmons |
| 9/25/1981 | | 13 | Bal | 10 | NYA | 7 | Stoddard | LaRoche | Schneider | Roenicke |
| 9/25/1981 | | | Tor | 7 | Cal | 3 | Leal | Zahn | | Velez |
| 9/25/1981 | | 10 | Sea | 9 | KC | 7 | Parrott | Martin | Andersen,L | Bochte |
| 9/25/1981 | | | Tex | 15 | Min | 4 | Hough | Williams | | Bell |
| 9/25/1981 | | | ChA | 7 | Oak | 1 | Dotson | Norris | | Hairston |
| 9/25/1981 | | | Phi | 2 | ChN | 1 | Larson | Eastwick | Reed,R | Matthews |
| 9/25/1981 | | | NYN | 2 | Mon | 5 | Gullickson | Marshall | Reardon | Milner |
| 9/25/1981 | | | Pit | 6 | StL | 1 | Solomon | Kaat | | Robinson,B |
| 9/25/1981 | | | Cin | 10 | Atl | 2 | Soto | Boggs | | Concepcion |
| 9/25/1981 | | 17 | LA | 6 | Hou | 2 | Forster | Niekro | | Guerrero |
| 9/25/1981 | | | SF | 8 | SD | 10 | Lucas | Minton | | Richards |
| 9/26/1981 | | | Cle | 8 | Bos | 5 | Glynn | Eckersley | Spillner | Kuiper |
| 9/26/1981 | | | Mil | 2 | Det | 1 | Haas | Wilcox | Fingers | Brouhard |
| 9/26/1981 | | | Bal | 4 | NYA | 5 | May | Flanagan | Castro | Winfield |
| 9/26/1981 | | | Tor | 0 | Cal | 3 | Renko | Berenguer | | Sconiers |
| 9/26/1981 | | | Sea | 3 | KC | 5 | Gale | Rawley | Quisenberry | Brett,G |
| 9/26/1981 | | | Tex | 6 | Min | 3 | Darwin | Arroyo | Comer | Roberts |
| 9/26/1981 | | 11 | ChA | 4 | Oak | 3 | Farmer | Owchinko | Hoyt | Lemon |
| 9/26/1981 | | | NYN | 3 | Mon | 2 | Harris | Burris | Marshall | Valentine |
| 9/26/1981 | | | Pit | 3 | StL | 11 | Forsch | Tiant | | Iorg |
| 9/26/1981 | | | Cin | 0 | Atl | 2 | Niekro | Berenyi | | Runge |
| 9/26/1981 | | | LA | 6 | Hou | 5 | Goltz | LaCorte | | Thomas |
| 9/26/1981 | | | SF | 4 | SD | 1 | Whitson | Kuhaulua | | Herndon |
| 9/27/1981 | | | Cle | 8 | Bos | 10 | Ojeda | Barker | Stanley | Rice |
| 9/27/1981 | | | Mil | 8 | Det | 5 | Lerch | Petry | Fingers | Simmons |
| 9/27/1981 | | | Bal | 0 | NYA | 4 | Righetti | Martinez,D | | Winfield |
| 9/27/1981 | | | Tor | 5 | Cal | 4 | Murray | Moreno | McLaughlin | Bonnell |
| 9/27/1981 | | | Sea | 6 | KC | 2 | Clay | Jones | Galasso | Zisk |
| 9/27/1981 | | | Tex | 4 | Min | 3 | Butcher | Redfern | Comer | Wagner |
| 9/27/1981 | | | NYN | 2 | Mon | 8 | Rogers | Scott | | Rogers |
| 9/27/1981 | | | Pit | 5 | StL | 6 | Sutter | Perez | Littell | Hendrick |
| 9/27/1981 | | | Cin | 5 | Atl | 1 | Seaver | Perry | | Knight |
| 9/27/1981 | | | LA | 1 | Hou | 3 | Sutton | Valenzuela | Smith,D | Thon |
| 9/27/1981 | | | SF | 3 | SD | 2 | Alexander | Welsh | Breining | Martin |
| 9/27/1981 | 1 | | ChA | 3 | Oak | 7 | Langford | Baumgarten | | Klutts |
| 9/27/1981 | 1 | | Phi | 10 | ChN | 1 | Carlton | Bird | | Matthews |
| 9/27/1981 | 2 | | ChA | 0 | Oak | 2 | Keough | Koosman | | Murphy |
| 9/27/1981 | 2 | | Phi | 2 | ChN | 0 | Ruthven | Krukow | Reed,R | McBride |
| 9/28/1981 | | | NYA | 6 | Cle | 7 | Monge | Castro | | Harrah |
| 9/28/1981 | | 13 | Bal | 7 | Det | 6 | Luebber | Tobik | | DeCinces |
| 9/28/1981 | | | Bos | 3 | Mil | 5 | Vuckovich | Tanana | Fingers | |
| 9/28/1981 | | | Cal | 7 | ChA | 3 | Sanchez | Farmer | | Downing |
| 9/28/1981 | | 11 | KC | 7 | Min | 6 | Gale | Felton | | Brett,G |
| 9/28/1981 | | | Tex | 8 | Sea | 4 | Honeycutt | Abbott | | Roberts |
| 9/28/1981 | | | NYN | 1 | Phi | 2 | Noles | Lynch | Reed,R | Rose |
| 9/28/1981 | | | Mon | 1 | StL | 3 | Martin | Sanderson | Sutter | Hendrick |
| 9/28/1981 | | 10 | LA | 2 | Atl | 1 | Stewart | Garber | | Johnstone |
| 9/28/1981 | | | SF | 3 | Cin | 7 | Pastore | Hargesheimer | | Oester |
| 9/28/1981 | | | SD | 0 | Hou | 2 | Niekro | Eichelberger | | Niekro |
| 9/28/1981 | 1 | | ChN | 1 | Pit | 5 | Rhoden | Griffin | | Parker |
| 9/28/1981 | 2 | | ChN | 6 | Pit | 0 | Geisel | Long | | Durham |
| 9/29/1981 | | | NYA | 7 | Cle | 3 | Guidry | Denny | | Brown |
| 9/29/1981 | | | Bal | 5 | Det | 9 | Morris | McGregor | | Kemp |
| 9/29/1981 | | | Bos | 1 | Mil | 2 | Easterly | Torrez | Augustine | Thomas |
| 9/29/1981 | | | Cal | 0 | ChA | 1 | Dotson | Kison | Hoyt | Squires |
| 9/29/1981 | | | KC | 9 | Min | 6 | Brett,K | Jackson,D | Quisenberry | Otis |
| 9/29/1981 | | | Tor | 2 | Oak | 3 | Underwood | Clancy | Jones | Murphy |
| 9/29/1981 | | | Tex | 5 | Sea | 4 | Medich | Clark | Comer | Putnam |
| 9/29/1981 | | | NYN | 8 | Phi | 1 | Falcone | Davis,M | | Brooks |
| 9/29/1981 | | 14 | ChN | 5 | Pit | 6 | Long | Hernandez | | Thompson |
| 9/29/1981 | | | Mon | 3 | StL | 1 | Lee | Andujar | Fryman | Scott |
| 9/29/1981 | | | LA | 4 | Atl | 3 | Welch | Bradford | Howe | Thomas |
| 9/29/1981 | | | SF | 7 | Cin | 4 | Ripley | Leibrandt | Breining | Leonard |
| 9/29/1981 | | | SD | 0 | Hou | 3 | Knepper | Wise | | Reynolds |
| 9/30/1981 | | | Bos | 2 | Mil | 0 | Hurst | Caldwell | Clear | Rice |
| 9/30/1981 | | | Cal | 5 | ChA | 3 | Frost | Burns | Aase | |
| 9/30/1981 | | | KC | 6 | Min | 1 | Gura | Arroyo | | Wilson |
| 9/30/1981 | | | Tor | 2 | Oak | 3 | Norris | Leal | Jones | Spencer |
| 9/30/1981 | | | Tex | 6 | Sea | 0 | Hough | Bannister | | Roberts |
| 9/30/1981 | | | ChN | 2 | NYN | 14 | Puleo | Bird | | Kingman |
| 9/30/1981 | | | StL | 4 | Phi | 2 | Sykes | Larson | Kaat | Hernandez |
| 9/30/1981 | | | Mon | 4 | Pit | 2 | Gullickson | Solomon | Reardon | Francona |
| 9/30/1981 | | | SF | 2 | Atl | 4 | McWilliams | Whitson | Camp | Hubbard |
| 9/30/1981 | | | Hou | 4 | Cin | 9 | Soto | Ruhle | | Concepcion |
| 9/30/1981 | | | SD | 7 | LA | 10 | Pena | Lucas | Howe | Garvey |
| 10/1/1981 | | | Bal | 2 | Det | 3 | Cappuzzello | Stoddard | | Cowens |
| 10/1/1981 | | | StL | 6 | Phi | 4 | Sykes | Proly | Kaat | Hendrick |
| 10/1/1981 | | | Mon | 0 | Pit | 1 | Tiant | Sosa | | Easler |
| 10/1/1981 | | 16 | SF | 2 | Atl | 3 | Matula | Breining | | Smith |
| 10/1/1981 | | | Hou | 9 | Cin | 8 | Ryan | Berenyi | LaCorte | Ryan |
| 10/1/1981 | | | SD | 2 | LA | 6 | Valenzuela | Kuhaulua | | Garvey |
| 10/2/1981 | | | NYA | 4 | Bal | 0 | Righetti | Schneider | | Revering |
| 10/2/1981 | | | Bos | 6 | Cle | 11 | Barker | Tudor | | Orta |
| 10/2/1981 | | | Det | 5 | Mil | 1 | Petry | Haas | | Leach |
| 10/2/1981 | | | Min | 2 | ChA | 3 | Koosman | Corbett | | |
| 10/2/1981 | | | Oak | 2 | KC | 1 | McCatty | Leonard | Owchinko | Gross |
| 10/2/1981 | | | Tor | 4 | Sea | 2 | Berenguer | Clay | McLaughlin | Woods |
| 10/2/1981 | | 13 | Cal | 5 | Tex | 6 | Comer | Jefferson | | Rivers |
| 10/2/1981 | | | Mon | 0 | NYN | 2 | Zachry | Rogers | Allen | Staub |
| 10/2/1981 | | | ChN | 3 | Phi | 0 | Eastwick | Carlton | Martz | Durham |
| 10/2/1981 | | | StL | 1 | Pit | 8 | Perez | LaPoint | | Robinson,B |
| 10/2/1981 | | | Atl | 0 | Cin | 2 | Pastore | Perry | Hume | Griffey |
| 10/2/1981 | | | Hou | 7 | LA | 1 | Sutton | Pena | | Pujols |
| 10/3/1981 | | | NYA | 2 | Bal | 4 | McGregor | John | Stoddard | Dauer |
| 10/3/1981 | | | Bos | 8 | Cle | 4 | Stanley | Brennan | Burgmeier | Gedman |
| 10/3/1981 | | | Det | 5 | Mil | 2 | Morris | Vuckovich | Saucier | Gibson |
| 10/3/1981 | | 10 | Min | 1 | ChA | 4 | Lamp | Corbett | | Nordhagen |
| 10/3/1981 | | | Oak | 3 | KC | 4 | Jones | Langford | Quisenberry | Brett,G |
| 10/3/1981 | | | Tor | 0 | Sea | 3 | Abbott | Stieb | | Anderson,J |
| 10/3/1981 | | | Cal | 2 | Tex | 7 | Comer | Moreno | | Tolleson |
| 10/3/1981 | | | Mon | 8 | NYN | 2 | Sanderson | Scott | | Sanderson |
| 10/3/1981 | | | ChN | 1 | Phi | 13 | Noles | Howell | | Trillo |
| 10/3/1981 | | | StL | 4 | Pit | 3 | Sutter | Lee | Kaat | Templeton |
| 10/3/1981 | | | Atl | 5 | Cin | 4 | Camp | Edelen | Bradford | Chambliss |
| 10/3/1981 | | | Hou | 3 | LA | 4 | Howe | Sambito | Stewart | Monday |
| 10/3/1981 | 1 | | SD | 4 | SF | 6 | Rowland | Eichelberger | Ripley | Bergman |
| 10/3/1981 | 2 | | SD | 1 | SF | 4 | Hargesheimer | Lollar | Ripley | |
| 10/4/1981 | | 12 | NYA | 2 | Bal | 1 | Gossage | Stoddard | | Robertson |
| 10/4/1981 | | | Bos | 6 | Cle | 5 | Clear | Monge | | Perez |
| 10/4/1981 | | | Det | 7 | Mil | 1 | Wilcox | Lerch | | Gibson |
| 10/4/1981 | | | Min | 1 | ChA | 0 | Williams | Dotson | Cooper | Corcoran |
| 10/4/1981 | | | Oak | 2 | KC | 5 | Gura | Keough | Quisenberry | |
| 10/4/1981 | | | Tor | 3 | Sea | 2 | Todd | Bannister | McLaughlin | Wells |
| 10/4/1981 | | | Cal | 6 | Tex | 5 | Aase | Babcock | D'Acquisto | Grich |
| 10/4/1981 | | 15 | Mon | 3 | NYN | 0 | Gorman | Searage | | Dawson |
| 10/4/1981 | | | ChN | 6 | Phi | 7 | McGraw | Caudill | | Smith |
| 10/4/1981 | | | StL | 5 | Pit | 6 | Jones | Shirley | Scurry | Ray |
| 10/4/1981 | | | Atl | 2 | Cin | 5 | Soto | Boggs | Price | O'Berry |
| 10/4/1981 | | | Hou | 7 | LA | 3 | Knepper | Hooton | | Loucks |
| 10/4/1981 | | | SD | 3 | SF | 4 | Minton | Urrea | Breining | May |
| 10/5/1981 | | 10 | KC | 9 | Cle | 6 | Quisenberry | Spillner | Gale | Brett,G |